Deng Li, Huang Yan, Li Ling, Chen Hongfei, Su Junyou
Department of Obstetrics, the Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
J Int Med Res. 2020 Sep;48(9):300060520954763. doi: 10.1177/0300060520954763.
To evaluate serum microRNA (miR)-29a/b expression in gestational diabetes mellitus (GDM) and its influence on neonatal prognosis.
This was a retrospective study including 68 pregnant women with GDM (GDM group) and 55 healthy pregnant women of similar age range and gestation period (healthy group).
The area under the curve was 0.829 for the diagnosis of GDM using serum miR-29a expression, 0.857 for diagnosis using serum miR-29b expression, and 0.944 for combined diagnosis (using both miR-29a and miR-29b). The fasting insulin (FINS) level of the GDM group was significantly lower than that of the healthy group; levels of fasting plasma glucose (FPG), 2-h plasma glucose (2hPG), and glycated hemoglobin (HbA1c) were significantly higher in the GDM group than in the healthy group. Both miR-29a and miR-29b were positively correlated with FINS levels and negatively correlated with FPG, 2hPG, and HbA1c levels. Serum miR-29a/b expression in pregnant women with GDM was not correlated with neonatal weight, premature delivery, or asphyxia but was correlated with pathologic jaundice.
Serum miR-29a/b expression was downregulated in pregnant women with GDM and correlated with neonatal pathologic jaundice, showing good individual (miR-29a or miR-29b) diagnostic value and excellent combined (miR-29a and miR-29b) diagnostic value.
评估妊娠糖尿病（GDM）患者血清微小RNA（miR）-29a/b的表达及其对新生儿预后的影响。
本研究为回顾性研究，纳入68例GDM孕妇（GDM组）和55例年龄范围及孕周相似的健康孕妇（健康组）。
血清miR-29a表达诊断GDM的曲线下面积为0.829，血清miR-29b表达诊断的曲线下面积为0.857，联合诊断（同时使用miR-29a和miR-29b）的曲线下面积为0.944。GDM组空腹胰岛素（FINS）水平显著低于健康组；GDM组空腹血糖（FPG）、餐后2小时血糖（2hPG）和糖化血红蛋白（HbA1c）水平显著高于健康组。miR-29a和miR-29b均与FINS水平呈正相关，与FPG、2hPG和HbA1c水平呈负相关。GDM孕妇血清miR-29a/b表达与新生儿体重、早产或窒息无关，但与病理性黄疸有关。
GDM孕妇血清miR-29a/b表达下调，且与新生儿病理性黄疸相关，显示出良好的单项（miR-29a或miR-29b）诊断价值和优异的联合（miR-29a和miR-29b）诊断价值。
