NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China.
Mol Cancer. 2020 Feb 4;19(1):22. doi: 10.1186/s12943-020-1147-3.
Non-coding RNAs do not encode proteins and regulate various oncological processes. They are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics and translation omics have begun to elucidate the roles and modes of action of the functional peptides encoded by ncRNA. Here, recent advances in long non-coding RNA (lncRNA) and circular RNA (circRNA)-encoded small peptides are compiled and synthesized. We introduce both the computational and analytical methods used to forecast prospective ncRNAs encoding oncologically functional oligopeptides. We also present numerous specific lncRNA and circRNA-encoded proteins and their cancer-promoting or cancer-inhibiting molecular mechanisms. This information may expedite the discovery, development, and optimization of novel and efficacious cancer diagnostic, therapeutic, and prognostic protein-based tools derived from non-coding RNAs. The role of ncRNA-encoding functional peptides has promising application perspectives and potential challenges in cancer research. The aim of this review is to provide a theoretical basis and relevant references, which may promote the discovery of more functional peptides encoded by ncRNAs, and further develop novel anticancer therapeutic targets, as well as diagnostic and prognostic cancer markers.
非编码 RNA 不编码蛋白质，而是调控各种肿瘤发生过程。它们也是重要的潜在癌症诊断和预后生物标志物。生物信息学和翻译组学已开始阐明 ncRNA 编码的功能肽的作用和作用模式。在此，我们对长链非编码 RNA（lncRNA）和环状 RNA（circRNA）编码小肽的最新进展进行了汇编和综合。我们介绍了用于预测具有潜在致癌功能的寡肽的 ncRNA 的计算和分析方法。我们还介绍了许多特定的 lncRNA 和 circRNA 编码蛋白及其促进或抑制癌症的分子机制。这些信息可能会加速基于非编码 RNA 的新型有效癌症诊断、治疗和预后蛋白工具的发现、开发和优化。ncRNA 编码功能肽的作用在癌症研究中具有广阔的应用前景和潜在挑战。本综述的目的是为 ncRNA 编码功能肽的发现提供理论依据和相关参考，以促进更多功能肽的发现，并进一步开发新的抗癌治疗靶点以及癌症诊断和预后标志物。
