Department of Dental Materials, National University of Medical Sciences (NUMS), Rawalpindi, Pakistan.
Interdisciplinary Research Centre in Biomedical Materials (IRCBM) COMSATS University Islamabad, Lahore Campus, Pakistan.
Mater Sci Eng C Mater Biol Appl. 2020 Sep;114:111040. doi: 10.1016/j.msec.2020.111040. Epub 2020 May 1.
Secondary caries is one of the most major cause for re-placement of dental composite restorations. Targeting the survival of cariogenic bacteria residing on the restoration surface may reduce this problem. The present study aims to evaluate the antibacterial potential as well as assess the physical and chemical properties of experimental dental composites containing novel drug-decorated copper particles (DDCP) as adjunct antibacterial filler particles. These were incorporated at concentrations of 0%, 0.5%, 0.10%, 0.20%, and 0.25% (w/w) into experimental composite consisting of methacrylate monomers and silanized silica fillers. RESULTS: Direct contact test revealed that the anti-cariogenic potential of experimental composites was more than the control groups. The cell viability assay showed no toxic effect on MC3T3-E1 cell lines in the MTT assay. The microhardness of experimental composites increased as the percentage of DDCP increased, however, the degree of cure was increased only up till the concentration of 0.20%. The release kinetics of the composites reveals that even after 28 days there was a steady and slow release of copper particles signifying the sustained anti-cariogenic effect. CONCLUSION: The experimental composites have good anti-cariogenic potential, which was sustained for one month without any deleterious effect on the physical and chemical properties of resin dental composites.
继发龋是导致牙体复合树脂修复体更换的主要原因之一。针对驻留在修复体表面的致龋菌的存活情况，可以减少这个问题。本研究旨在评估含有新型药物修饰铜颗粒（DDCP）的实验性牙科复合材料的抗菌潜力，并评估其物理和化学性能，这些颗粒作为附加抗菌填料颗粒。这些颗粒以 0%、0.5%、0.10%、0.20%和 0.25%（w/w）的浓度掺入由甲基丙烯酸酯单体和硅烷化二氧化硅填料组成的实验性复合材料中。结果：直接接触试验表明，实验性复合材料的抗龋潜力超过对照组。细胞活力测定显示，在 MTT 测定中，对 MC3T3-E1 细胞系没有毒性作用。实验性复合材料的显微硬度随着 DDCP 百分比的增加而增加，但固化程度仅在 0.20%的浓度下增加。复合材料的释放动力学表明，即使在 28 天后，铜颗粒仍能稳定且缓慢释放，表明具有持续的抗龋效果。结论：实验性复合材料具有良好的抗龋潜力，且在一个月内没有对树脂牙科复合材料的物理和化学性质产生任何有害影响。
