Ding Yuan, Xu Hao, Xu Chang, Tong Zongrui, Zhang Sitong, Bai Yang, Chen Yining, Xu Qianhui, Zhou Liuzhi, Ding Hao, Sun Zhongquan, Yan Sheng, Mao Zhengwei, Wang Weilin
Department of Hepatobiliary and Pancreatic Surgery the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310009 China.
Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province Hangzhou Zhejiang 310009 China.
Adv Sci (Weinh). 2020 Jun 14;7(17):2001060. doi: 10.1002/advs.202001060. eCollection 2020 Sep.
The incorporation of new modalities into chemotherapy greatly enhances the anticancer efficacy combining the merits of each treatment, showing promising potentials in clinical translations. Herein, a hybrid nanomedicine () is fabricated using metal-organic framework (MOF) nanoparticles and gold nanoparticles (Au NPs) as building blocks for cancer chemo/chemodynamic therapy. MOF NPs are used as vehicles to encapsulate camptothecin (CPT), and the hybridization by Au NPs greatly improves the stability of the nanomedicine in a physiological environment. Triggered by the high concentration of phosphate inside the cancer cells, effectively collapse after internalization, resulting in the complete drug release and activation of the cascade catalytic reactions. The intracellular glucose can be oxidized by Au NPs to produce hydrogen dioxide, which is further utilized as chemical fuel for the Fenton reaction, thus realizing the synergistic anticancer efficacy. Benefitting from the enhanced permeability and retention effect and sophisticated fabrications, the blood circulation time and tumor accumulation of are significantly increased. In vivo results demonstrate that the combination of chemotherapy and chemodynamic therapy effectively suppresses the tumor growth, meantime the systemic toxicity of this nanomedicine is greatly avoided.
将新的治疗方式纳入化疗可极大地提高抗癌疗效，结合每种治疗方法的优点，在临床转化中显示出广阔的潜力。在此，一种杂化纳米药物（）被制备出来，它以金属有机框架（MOF）纳米颗粒和金纳米颗粒（Au NPs）作为构建单元用于癌症化疗/化学动力疗法。MOF NPs用作载体来包裹喜树碱（CPT），并且与Au NPs的杂化极大地提高了纳米药物在生理环境中的稳定性。在癌细胞内高浓度磷酸盐的触发下，内化后有效地解体，导致药物完全释放并激活级联催化反应。细胞内的葡萄糖可被Au NPs氧化产生过氧化氢，其进一步被用作芬顿反应的化学燃料，从而实现协同抗癌疗效。受益于增强的渗透和滞留效应以及精细的制备工艺，的血液循环时间和肿瘤蓄积显著增加。体内结果表明，化疗和化学动力疗法的联合有效地抑制了肿瘤生长，同时极大地避免了这种纳米药物的全身毒性。
