Xia Xiancheng, Li Yang, Huang Rongkang, Wang Yuanbin, Xiong Wenxuan, Zhou Hui, Li Min, Lin Xidong, Tang Youchen, Zhang Bo
Department of Interventional Center, Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, P. R. China.
The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518033, P. R. China.
Adv Sci (Weinh). 2025 Feb;12(5):e2410873. doi: 10.1002/advs.202410873. Epub 2024 Dec 10.
Transarterial chemoembolization (TACE) utilizing a water-in-oil lipiodol emulsion is a preferable therapeutic strategy for advanced liver cancer in clinical practice. However, the low stability of the lipiodol emulsion and poor efficacy of chemotherapeutic drug seriously undermine the efficiency of TACE. Herein, a novel lobaplatin-loaded lipiodol emulsion (denoted as ICN-LPE) is developed by constructing a lipiodol Pickering emulsion (LPE) stabilized with iron-doped carbon nanozymes (ICN) to mitigate the issue of lipiodol-water separation. This novel emulsion not only solves the instability of conventional lipiodol emulsions, but also facilitates the sustained release of lobaplatin. More importantly, upon entry into tumor cells, ICN catalyze the generation of reactive oxygen species via the Fenton-like reaction while simultaneously consuming intracellular glutathione, thereby inducing tumor cell death via chemodynamic therapy. By integrating chemotherapy and chemodynamic therapy, ICN-LPE demonstrates a synergistic antitumor effect and effectively inhibits tumor growth in a rabbit liver tumor model. Therefore, our ICN-LPE shows an appealing clinical application prospect for TACE.
在临床实践中，利用油包水型碘油乳剂进行经动脉化疗栓塞（TACE）是晚期肝癌的一种优选治疗策略。然而，碘油乳剂的稳定性低以及化疗药物疗效差严重影响了TACE的效率。在此，通过构建用铁掺杂碳纳米酶（ICN）稳定的碘油皮克林乳液（LPE）来开发一种新型的载洛铂碘油乳液（称为ICN-LPE），以缓解碘油-水分离问题。这种新型乳液不仅解决了传统碘油乳液的不稳定性，还促进了洛铂的持续释放。更重要的是，进入肿瘤细胞后，ICN通过类芬顿反应催化活性氧的产生，同时消耗细胞内谷胱甘肽，从而通过化学动力疗法诱导肿瘤细胞死亡。通过整合化疗和化学动力疗法，ICN-LPE在兔肝肿瘤模型中显示出协同抗肿瘤作用并有效抑制肿瘤生长。因此，我们的ICN-LPE在TACE方面显示出有吸引力的临床应用前景。
