组织蛋白酶 G 降解金黄色葡萄球菌生物膜。
Cathepsin G Degrades Staphylococcus aureus Biofilms.
机构信息
Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Inflammation Program, Department of Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
出版信息
J Infect Dis. 2021 Jun 4;223(11):1865-1869. doi: 10.1093/infdis/jiaa612.
Abstract
Polymorphonuclear leukocytes (PMN) phagocytose and kill individual bacteria but are far less efficient when challenged with bacterial aggregates. Consequently, growth within a biofilm affords Staphylococcus aureus some protection but PMN penetrate S. aureus biofilms and phagocytose bacteria, suggesting that enzymes released through neutrophil degranulation degrade biofilms into fragments small enough for phagocytosis. Here we show that the capacity of PMN to invade biofilms depended largely on the activity of secreted cathepsin G.
摘要
多形核白细胞（PMN）可以吞噬和杀死单个细菌，但在遇到细菌聚集时效率要低得多。因此，在生物膜内生长为金黄色葡萄球菌提供了一些保护，但 PMN 可以穿透金黄色葡萄球菌生物膜并吞噬细菌，这表明通过中性粒细胞脱颗粒释放的酶将生物膜降解成足够小的片段，以便吞噬。在这里，我们表明 PMN 入侵生物膜的能力在很大程度上取决于分泌的组织蛋白酶 G 的活性。
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本文引用的文献
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