Division of Nephrology, University of Virginia, Charlottesville, Virginia, USA.
School of Nursing, University of Virginia, Charlottesville, Virginia, USA.
J Palliat Med. 2021 Apr;24(4):536-544. doi: 10.1089/jpm.2020.0153. Epub 2020 Sep 30.
Despite evidence that advance care planning (ACP) benefits patients with serious illnesses, there is a dearth of information about "who" is referred for palliative care (PC) consultation, the rate of PC consultation, and the outcomes of referrals in patients with advanced chronic kidney disease/end-stage kidney disease (aCKD/ESKD). (1) To describe patient characteristics associated with PC consultations and (2) to determine the frequency and outcome of PC consultation on documented ACP discussions for patients with aCKD/ESKD. This is retrospective observational electronic health record cohort review. University of Virginia (UVA) hospital, clinics, and dialysis units. Patients were studied along two time intervals. Time period January 1, 2015 to June 30, 2017 included all patients admitted to UVA during that time period with estimated glomerular filtration rate (eGFR) <60 mL/minute. Time period January 1, 2018 to March 31, 2019 included two cohorts: patients with eGFR <15 mL/minute who had died during study period excluding those who withdrew from dialysis and those who were dialysis dependent and withdrew from dialysis. Aside from higher rates of PC consultation in patients with heart failure, none of the demographic and comorbidity data studied affected whether or not a patient is referred to PC in patients with aCKD/ESKD. PC consultation rates were low among all patients studied: 14.7% in patients with eGFR <60 mL/minute, 28.9% in dialysis patients withdrawing from dialysis, and 57.1% in terminally ill patients with eGFR <15 mL/minute. In all cohorts, PC consultations were associated with improved ACP. PC consultation is significantly associated with better end-of-life outcomes with more completion of ACP and hospice referral in patients with aCKD/ESKD. PC consultation rates remain low. Even in terminally ill patients with more aCKD, >40% were never seen by PC. Until policies and curricula better prepare nephrologists to independently address ACP, collaboration between nephrologists and PC specialists is recommended.
尽管有证据表明预先医疗计划(ACP)使患有严重疾病的患者受益,但关于“谁”被推荐进行姑息治疗(PC)咨询、PC 咨询的比率以及在患有晚期慢性肾脏病/终末期肾病(aCKD/ESKD)的患者中的转诊结果的信息却很少。(1)描述与 PC 咨询相关的患者特征,以及(2)确定在有 aCKD/ESKD 患者的记录 ACP 讨论中 PC 咨询的频率和结果。这是一项回顾性观察性电子健康记录队列研究。弗吉尼亚大学(UVA)医院、诊所和透析单位。患者在两个时间间隔内进行研究。2015 年 1 月 1 日至 2017 年 6 月 30 日期间,包括在此期间因估计肾小球滤过率(eGFR)<60ml/min 而入住 UVA 的所有患者;2018 年 1 月 1 日至 2019 年 3 月 31 日期间,包括两个队列:研究期间死亡的 eGFR<15ml/min 的患者,不包括退出透析的患者和依赖透析并退出透析的患者。除心力衰竭患者的 PC 咨询率较高外,在所研究的患者中,没有任何人口统计学和合并症数据影响患者是否被推荐进行 PC 咨询。在所有研究患者中,PC 咨询率均较低:eGFR<60ml/min 的患者为 14.7%,退出透析的透析患者为 28.9%,eGFR<15ml/min 的终末期患者为 57.1%。在所有队列中,PC 咨询均与改善 ACP 相关。在患有 aCKD/ESKD 的患者中,PC 咨询与更好的临终结局显著相关,因为 ACP 的完成和临终关怀的转介更多。PC 咨询率仍然很低。即使在 eGFR 较低的终末期患者中,仍有>40%的患者从未接受过 PC 咨询。在肾脏病专家更好地制定政策和课程来独立处理 ACP 之前,建议肾脏病专家与姑息治疗专家合作。