O'Neill Robert Sean, Duong Tuan, Dionela Welan, Rogge Claudia, Brungs Daniel
Department of Oncology, The Wollongong Hospital, Wollongong, New South Wales, Australia.
Department of Gastroenterology, The Wollongong Hospital, Wollongong, New South Wales, Australia.
Case Rep Oncol. 2020 Aug 14;13(2):962-967. doi: 10.1159/000508745. eCollection 2020 May-Aug.
Non-small cell lung cancer (NSCLC) is characterised by diffuse metastases, with common sites being the brain, liver, bones, and adrenal glands. Small bowel metastasis from NSCLC is a rare phenomenon, particularly in patients with an adenocarcinoma histology. We report the case of a 56-year-old lung adenocarcinoma patient with a duodenal metastasis diagnosed on FDG/PET-CT and confirmed on duodenal biopsy. Although initially asymptomatic, he subsequently presented with obstructive jaundice secondary to rapid local disease progression at the duodenal metastasis, requiring endoscopic intervention for biliary drainage. He was commenced on single agent pembrolizumab, with disease response on subsequent follow-up. This case highlights a rare case of gastrointestinal metastasis from NSCLC requiring endoscopic intervention due to rapid progression of the disease at the site of metastasis.
非小细胞肺癌（NSCLC）的特征是发生弥漫性转移，常见转移部位包括脑、肝、骨和肾上腺。NSCLC发生小肠转移是一种罕见现象，在腺癌组织学类型的患者中尤为少见。我们报告一例56岁的肺腺癌患者，其十二指肠转移灶通过FDG/PET-CT诊断，并经十二指肠活检确诊。该患者最初无症状，但随后因十二指肠转移灶处疾病快速局部进展而出现梗阻性黄疸，需要内镜干预进行胆道引流。患者开始接受单药派姆单抗治疗，后续随访显示疾病有反应。该病例突出了NSCLC发生胃肠道转移的罕见情况，由于转移部位疾病快速进展而需要内镜干预。
