Nedialkova M, Mikhalev A, Tosheva R, Georgieva B
Vutr Boles. 1987;26(2):95-8.
The studies in the present work are a continuation of the previous studies of the author's on the functional activity of leukosis cells and discuss their fungicidal activity versus Candida albicans. Blast cells from 22 patients with various clinical-morphological forms of acute leukosis were studied. It has been concluded from the results obtained that leukosis cells of monoblast type in acute myelomonoblast (M4) and monoblast (M5) leukosis are able to lyse Candida albicans, the value of their fungicidal activity being lower than that of mature monocytes from peripheral blood of healthy subjects. The fungicidal activity is observed in leukosis cells from patients with promyelocyte (M3) leukosis. The authors propose the fungicidal activity of leukosis cells to be used as an additional, functional criterium in the differentiation of their type.
本研究工作是作者先前关于白血病细胞功能活性研究的延续，探讨了它们对白色念珠菌的杀真菌活性。研究了22例患有各种临床形态学类型急性白血病患者的原始细胞。从所得结果得出结论，急性粒单核细胞白血病（M4）和单核细胞白血病（M5）中单核母细胞类型的白血病细胞能够裂解白色念珠菌，其杀真菌活性值低于健康受试者外周血中成熟单核细胞的杀真菌活性值。在早幼粒细胞白血病（M3）患者的白血病细胞中观察到杀真菌活性。作者提出将白血病细胞的杀真菌活性用作其类型鉴别的附加功能标准。
