通过晚期 [C]、[C] 和 [C] 二氧化碳掺入对氨基甲酸酯进行碳同位素标记。
Carbon isotope labeling of carbamates by late-stage [C], [C] and [C]carbon dioxide incorporation.
机构信息
Université Paris-Saclay, Service de Chimie Bio-organique et Marquage (SCBM), CEA/DRF/JOLIOT, 91191, Gif sur Yvette, France.
UMR 1023 IMIV, Service Hospitalier Frédéric Joliot, CEA, Inserm, Université Paris Sud, CNRS, Université Paris-Saclay, Orsay, France.
出版信息
Chem Commun (Camb). 2020 Oct 1;56(78):11677-11680. doi: 10.1039/d0cc05031h.
A general procedure for the late-stage [11C], [13C] and [14C]carbon isotope labeling of cyclic carbamates is reported. This protocol allows the incorporation of carbon dioxide, the primary source of carbon-14 and carbon-11 radioisotopes, in a direct, cost-effective and sustainable manner. A disconnection/reconnection strategy, involving ring opening/isotopic closure, was also implemented.
本文报道了一种通用的后期[11C]、[13C]和[14C]碳同位素标记环状氨基甲酸酯的方法。该方案以直接、经济高效和可持续的方式，将二氧化碳（碳-14 和碳-11 放射性同位素的主要来源）掺入其中。还实施了一种涉及开环/同位素封闭的断开/连接策略。
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