Jobdeedamrong Arjaree, Theerasilp Man, Wongsuwan Nattarat, Nasongkla Norased, Crespy Daniel
Department of Materials Science and Engineering, School of Molecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology, 21210 Rayong, Thailand.
Chem Commun (Camb). 2020 Oct 28;56(84):12725-12728. doi: 10.1039/d0cc05287f. Epub 2020 Oct 1.
Herein, we design inflammation-responsive nanocapsules containing two antibiotics. The releases are programmed to be triggered under conditions occurring at the different stages of wound healing. The nanocapsules exhibit excellent antibacterial activities against Gram-positive, Gram-negative, and antibiotic-resistant bacteria. Incorporation of small amounts of nanocapsules in hydrogels leads to efficient antibacterial wound dressings.
在此，我们设计了含有两种抗生素的炎症响应性纳米胶囊。其释放过程被设定为在伤口愈合不同阶段出现的条件下触发。这些纳米胶囊对革兰氏阳性菌、革兰氏阴性菌和耐抗生素细菌均表现出优异的抗菌活性。在水凝胶中加入少量纳米胶囊可制成高效抗菌伤口敷料。
