Puzio Thaddeus J, Kozar Rosemary A
University of Texas Health Science Center at Houston, Houston, Texas.
Shock Trauma Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Curr Opin Crit Care. 2020 Dec;26(6):622-627. doi: 10.1097/MCC.0000000000000764.
The aim of this study was to discuss recent findings related to providing adequate and well tolerated nutrition to the critically ill surgical patient.
The majority of nutritional studies in the critically ill have been performed on well nourished patients, but validated scoring systems can now identify high nutrition risk patients. Although it remains well accepted that early enteral nutrition with protein supplementation is key, mechanistic data suggest that hypocaloric feeding in septic patients may be beneficial. For critically ill patients unable to tolerate enteral nutrition, randomized pilot data demonstrate improved functional outcomes with early supplemental parenteral nutrition. Current guidelines also recommend early total parenteral nutrition in high nutrition risk patients with contraindications to enteral nutrition. When critically ill patients require low or moderate-dose vasopressors, enteral feeding appears well tolerated based on a large database study, while randomized prospective data showed worse outcomes in patients receiving high-dose vasopressors.
Current evidence suggests early enteral nutrition with protein supplementation in critically ill surgical patients with consideration of early parenteral nutrition in high nutrition risk patients unable to achieve nutrition goals enterally. Despite established guidelines for nutritional therapy, the paucity of data to support these recommendations illustrates the critical need for additional studies.
本研究旨在探讨与为危重症外科患者提供充足且耐受性良好的营养相关的最新研究结果。
大多数针对危重症患者的营养研究是在营养状况良好的患者中进行的,但目前有效的评分系统能够识别出高营养风险患者。尽管早期肠内营养加蛋白质补充仍然是关键这一观点已被广泛接受,但机制数据表明,脓毒症患者采用低热量喂养可能有益。对于无法耐受肠内营养的危重症患者,随机试验数据表明早期补充肠外营养可改善功能结局。当前指南还建议,对于有肠内营养禁忌证的高营养风险患者,应早期给予全肠外营养。根据一项大型数据库研究,当危重症患者需要低剂量或中等剂量血管升压药时,肠内喂养似乎耐受性良好,而随机前瞻性数据显示,接受高剂量血管升压药的患者结局较差。
目前的证据表明,危重症外科患者应早期给予肠内营养并补充蛋白质,对于无法通过肠内途径实现营养目标的高营养风险患者,应考虑早期给予肠外营养。尽管有既定的营养治疗指南,但支持这些建议的数据匮乏,这表明迫切需要更多的研究。