Hustin J, Schaaps J P
Am J Obstet Gynecol. 1987 Jul;157(1):162-8. doi: 10.1016/s0002-9378(87)80371-x.
The initiation of uteroplacental circulation was investigated in early pregnancy with the following material: contact ultrasonography, 250 cases; direct-vision chorionic biopsy, 10 cases; products from voluntary interruption of pregnancy, 60 cases; and hysterectomy with the pregnancy in situ, three cases. Using all of these techniques, we were unable to demonstrate a true intervillous blood flow during the first 12 weeks. We suggest that during this period the intervillous space is bathed by an acellular fluid that could be plasma filtered by the trophoblastic shell and its endovascular cone. If this is the case, the physiology of early pregnancy must be reconsidered.
接触式超声检查，250例；直视绒毛活检，10例；人工流产产物，60例；原位妊娠子宫切除术，3例。运用所有这些技术，我们未能在妊娠的前12周内证实真正的绒毛间隙血流。我们认为在此期间，绒毛间隙被一种无细胞液所浸润，这种无细胞液可能是由滋养层壳及其血管内锥体滤过的血浆。如果是这样的话，必须重新考虑早期妊娠的生理学。
