Beth Israel Deaconess Medical Center, Department of Anesthesia, Critical Care, and Pain Medicine, Harvard Medical School, Boston, MA, USA.
Georgetown University School of Medicine, Washington, DC, USA.
Best Pract Res Clin Anaesthesiol. 2020 Sep;34(3):463-477. doi: 10.1016/j.bpa.2020.06.004. Epub 2020 Jul 2.
Chronic pain can be recurrent or constant pain that lasts for longer than 3 months and can result in disability, suffering, and a physical disturbance. Related to the complex nature of chronic pain, treatments have a pharmacological and non-pharmacological approach. Due to the opioid epidemic, alternative therapies have been introduced, and components of the plant Cannabis Sativa, Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) have gained recent interest as a choice of treatment. The exact mechanism for CBD is currently unknown, but unlike the CBD's psychoactive counterpart, THC, the side effects of CBD itself have been shown to be overall much more benign. The current pharmaceutical products for the treatment of chronic pain are known as nabiximols, and they contain a ratio of THC combined with CBD, which has been promising. This review focuses on the treatment efficacy of CBD, THC: CBD-based treatments for chronic pain and adverse events with each.
慢性疼痛是指持续时间超过 3 个月的反复发作或持续疼痛，可能导致残疾、痛苦和身体机能紊乱。鉴于慢性疼痛的复杂性质，治疗方法包括药理学和非药理学方法。由于阿片类药物泛滥，已经引入了替代疗法，大麻植物的成分 Δ9-四氢大麻酚（THC）和大麻二酚（CBD）最近作为一种治疗选择引起了人们的兴趣。CBD 的确切机制目前尚不清楚，但与 CBD 的精神活性对应物 THC 不同，CBD 本身的副作用被证明总体上更为良性。目前用于治疗慢性疼痛的药物产品是纳比西莫司，它含有 THC 与 CBD 的混合比例，效果令人期待。本综述重点关注 CBD、THC 的治疗效果：基于 CBD 和 THC 的治疗慢性疼痛的方法以及每种方法的不良反应。
