Miralles F S, Lopez-Soriano F, Puig M M, Perez D, Lopez-Rodriguez F
Anesth Analg. 1987 Jul;66(7):615-8.
A randomized double-blind study tested the analgesic effects of subarachnoid administration of salmon calcitonin (sCT) in acute postoperative pain. Sixty patients were grouped according to type of surgery (intraabdominal, extraabdominal, and lower extremities), subdivided into those given subarachnoid lidocaine 1 mg/kg plus sCT (100 IU) or lidocaine plus saline. Pain was evaluated by a descriptive scale 3, 6, 12, 24, 48, and 72 hr after surgery, as well as by the frequency of the patients' requests for postoperative analgesics. In all instances, the sCT-treated patients had significantly less postoperative pain. Similarly, the requests for analgesics was significantly lower or absent in the sCT-treated group. Minor side effects such as nausea and vomiting, abdominal pain, and "nervousness" were observed in a small number of sCT-treated patients. In our series of 30 patients, subarachnoid administration of sCT was an effective analgesic with minimal side effects. Its safety remains to be proved by further studies.
一项随机双盲研究测试了蛛网膜下腔注射鲑鱼降钙素（sCT）对急性术后疼痛的镇痛效果。60名患者根据手术类型（腹腔内、腹腔外和下肢）分组，再细分为接受蛛网膜下腔注射1mg/kg利多卡因加sCT（100IU）或利多卡因加生理盐水的患者。在术后3、6、12、24、48和72小时，通过描述性量表以及患者术后镇痛药物的使用频率来评估疼痛程度。在所有情况下，接受sCT治疗的患者术后疼痛明显减轻。同样，sCT治疗组患者对镇痛药的需求明显较低或无需求。少数接受sCT治疗的患者出现了恶心、呕吐、腹痛和“紧张”等轻微副作用。在我们的30例患者系列中，蛛网膜下腔注射sCT是一种有效的镇痛药，副作用极小。其安全性仍有待进一步研究证实。
