Peng Song-Yang, Wu Xin, Lu Ting, Cui Gang, Chen Gang
Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
Med Gas Res. 2020 Jul-Sep;10(3):125-129. doi: 10.4103/2045-9912.296043.
Alzheimer's disease is a neurodegenerative disease that mainly occurs in old age and early stages. Its main manifestations are memory impairment, aphasia, apraxia, loss of identity, abstract thinking and impairment of computing power, personality and behavior changes, etc. At present, the treatment of Alzheimer's disease only stays on reducing the disease and delaying the development, which is also a difficult problem to overcome in clinical practice. Hydrogen sulfide, as a third gaseous signal molecule after carbon monoxide and nitrogen monoxide, has become very popular in recent years. It shows very promising prospects in the Alzheimer's disease model. It can protect the nerve function and prevent the progress of the disease by affecting the amyloid precursor protein metabolism, anti-apoptosis, anti-inflammatory, and antioxidant pathways. Therefore, this article summarizes the relevant basic and clinical research of hydrogen sulfide in Alzheimer's disease, and discusses its progress and findings and mechanism characteristics.
阿尔茨海默病是一种主要发生在老年和早期阶段的神经退行性疾病。其主要表现为记忆障碍、失语、失用、身份识别丧失、抽象思维和计算能力受损、人格和行为改变等。目前，阿尔茨海默病的治疗仅停留在减轻病情和延缓发展上，这也是临床实践中难以攻克的难题。硫化氢作为继一氧化碳和一氧化氮之后的第三种气体信号分子，近年来备受关注。它在阿尔茨海默病模型中显示出非常有前景的前景。它可以通过影响淀粉样前体蛋白代谢、抗凋亡、抗炎和抗氧化途径来保护神经功能并阻止疾病进展。因此，本文总结了硫化氢在阿尔茨海默病中的相关基础和临床研究，并探讨了其进展、发现及机制特点。
