Ou Di, Yao Jincao, Jin Ju, Yan Meiying, Shi Kaiyuan, Zheng Qiuqing, Yang Chen, Xu Dong
Department of Ultrasound, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital); Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences, Hangzhou, China.
Department of Pathology, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital); Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences, Hangzhou, China.
J Cancer Res Ther. 2020 Sep;16(5):1056-1062. doi: 10.4103/jcrt.JCRT_913_19.
We analyzed the clinical features and ultrasound image features of follicular thyroid carcinoma (FTC) and follicular thyroid adenoma (FTA).
This study aimed to identify ultrasonographic differences and correlations between FTC and FTA. Meanwhile, ultrasonographic manifestations of thyroid follicular tumor were also retrospectively analyzed.
Using pathological results as the gold standard, the clinical and ultrasonic image characteristics of FTA and FTC were statistically analyzed, and the differences were analyzed.
A total of 304 patients who were diagnosed with FTC or FTA by pathology after thyroidectomy from March 2009 to March 2018 were enrolled in this study. Their ultrasonic images were analyzed; image features were extracted and correlation analyses for these features were conducted. Differences in ultrasonic images between FTC and FTA were also compared.
Independent sample t-test; Wilcoxon rank sum test; A Chi-square test: Univariate and multivariate logistic regression analyses.
When performing ultrasound diagnosis, attention should be paid to identify FTC and FTA in terms of age, nodular goiter conditions, nodular boundary conditions, internal echo, calcification, blood flow signals, thyroid imaging reporting and data system (TI-RADS) grading and cystic solidity conditions. Moreover, a multivariate logistic regression showed that the boundaries were unclear, and cystic degeneration, TI-RADS, hypoecho, nodular goiter, macrocalcification and microcalcification were associated with FTC. Among them, macrocalcification is a protective factor for thyroid follicular tumors, and other indicators are risk factors.
Ultrasound can provide valuable information for the identification of follicular neoplasms, but further research in this area is still necessary.
我们分析了滤泡状甲状腺癌（FTC）和滤泡状甲状腺腺瘤（FTA）的临床特征及超声图像特征。
本研究旨在明确FTC与FTA之间的超声差异及相关性。同时，对甲状腺滤泡性肿瘤的超声表现进行回顾性分析。
以病理结果为金标准，对FTA和FTC的临床及超声图像特征进行统计学分析，并分析差异。
本研究纳入了2009年3月至2018年3月期间行甲状腺切除术后经病理诊断为FTC或FTA的304例患者。分析其超声图像；提取图像特征并对这些特征进行相关性分析。还比较了FTC与FTA超声图像的差异。
独立样本t检验；Wilcoxon秩和检验；卡方检验；单因素和多因素logistic回归分析。
在进行超声诊断时，应注意从年龄、结节性甲状腺肿情况、结节边界情况、内部回声、钙化、血流信号、甲状腺影像报告和数据系统（TI-RADS）分级及囊实性情况等方面鉴别FTC和FTA。此外，多因素logistic回归显示边界不清、囊性变、TI-RADS、低回声、结节性甲状腺肿、粗大钙化和微小钙化与FTC相关。其中，粗大钙化是甲状腺滤泡性肿瘤的保护因素，其他指标为危险因素。
超声可为滤泡性肿瘤的鉴别提供有价值的信息，但该领域仍需进一步研究。
