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在资源匮乏环境下,儿童获得肾脏护理的挑战。

Challenges of access to kidney care for children in low-resource settings.

机构信息

Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.

Institute of Biomedical Ethics and the History of Medicine, University of Zurich, Zurich, Switzerland.

出版信息

Nat Rev Nephrol. 2021 Jan;17(1):33-45. doi: 10.1038/s41581-020-00338-7. Epub 2020 Oct 1.

Abstract

Kidney disease is a global public health concern across the age spectrum, including in children. However, our understanding of the true burden of kidney disease in low-resource areas is often hampered by a lack of disease awareness and access to diagnosis. Chronic kidney disease (CKD) in low-resource settings poses multiple challenges, including late diagnosis, the need for ongoing access to care and the frequent unavailability of costly therapies such as dialysis and transplantation. Moreover, children in such settings are at particular risk of acute kidney injury (AKI) owing to preventable and/or reversible causes - many children likely die from potentially reversible kidney disease because they lack access to appropriate care. Acute peritoneal dialysis (PD) is an important low-cost treatment option. Initiatives, such as the Saving Young Lives programme, to train local medical staff from low-resource areas to provide care for AKI, including acute PD, have already saved hundreds of children. Future priorities include capacity building for both educational purposes and to provide further resources for AKI management. As local knowledge and confidence increase, CKD management strategies should also develop. Increased awareness and advocacy at both the local government and international levels will be required to continue to improve the diagnosis and treatment of AKI and CKD in children worldwide.

摘要

肾脏疾病是一个全球性的公共卫生问题,影响着各个年龄段的人群,包括儿童。然而,由于缺乏对疾病的认识以及诊断的机会,我们对资源匮乏地区肾脏疾病的真实负担往往了解不足。在资源匮乏的环境中,慢性肾脏病(CKD)面临着诸多挑战,包括诊断较晚、需要持续获得医疗护理以及频繁无法获得透析和移植等昂贵治疗方法。此外,由于可预防和/或可逆转的原因,这些环境中的儿童尤其容易出现急性肾损伤(AKI)——许多儿童可能因无法获得适当的护理而死于潜在可逆转的肾脏疾病。急性腹膜透析(APD)是一种重要的低成本治疗选择。“拯救儿童生命倡议”等举措已经培训了来自资源匮乏地区的当地医务人员,为 AKI 提供护理,包括急性 PD,已经拯救了数百名儿童。未来的重点包括为 AKI 管理提供进一步的资源以及用于教育目的的能力建设。随着当地知识和信心的增强,CKD 管理策略也应随之发展。需要在地方政府和国际层面提高认识和宣传,以继续改善全球儿童 AKI 和 CKD 的诊断和治疗。

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