Lv Jian, Zhou Qun, Wang Shuangle, Wei Fengqin, Zhang Xiaozheng, Zhang Luyao, Ni Haibin
Emergency Department, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 100 Shizi Road, Nanjing 210028, China.
Department of Pathology, School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China.
Evid Based Complement Alternat Med. 2020 Sep 14;2020:2983589. doi: 10.1155/2020/2983589. eCollection 2020.
This study evaluates the clinical efficacy of activated charcoal combined with mannitol (ACM) for the treatment of Haff disease. This is a retrospective cohort study conducted at the Emergency Department of Affiliated Hospital of Integrated Traditional Chinese and Western Medicine. Consecutive patients who were hospitalized during a two-year time frame (from June 2016 to August 2017) and diagnosed with Haff disease were reviewed. Clinical symptoms, laboratory findings, pain/anxiety scores, and treatment-related adverse events were collected. Sixty-eight Haff disease patients after boiled crayfish consumption were enrolled in this study. Besides standard treatments for Haff disease, 22 patients had an oral administration of activated charcoal and mannitol within 12 hours of hospital admission (ACM group), while the other 46 patients did not receive such treatment (non-ACM group). Baseline characteristics including clinical symptoms, serum enzyme levels, and pain/anxiety scores were comparable between the two groups. Activated charcoal and mannitol treatment led to lower CK-MB and AST levels from 12 hours to 60 hours, lower ALT and LDH levels from 12 hours to 72 hours, and lower CK levels from 24 hours to 72 hours after hospitalization. Patients in the ACM group had significantly shortened duration of hospital stays (7.5 [6.0-8.0] days vs 8.0 [6.8-10.0] days, = 0.032) and lower anxiety scores 24 hours after hospital admission (40.7 ± 4.9 vs 44.1 ± 6.3, = 0.032) than in the non-ACM group. No patient experienced treatment-related adverse events. The overall prognosis of both groups is good. Among patients with Haff disease caused by boiled crayfish, activated charcoal combined with mannitol treatment resulted in shorter hospital stays, lower serum CK, CK-MB, AST, ALT, and LDH levels, and lower anxiety scores.
本研究评估活性炭联合甘露醇（ACM）治疗哈夫病的临床疗效。这是一项在中西医结合附属医院急诊科进行的回顾性队列研究。对在两年时间内（2016年6月至2017年8月）住院并被诊断为哈夫病的连续患者进行了回顾。收集了临床症状、实验室检查结果、疼痛/焦虑评分以及与治疗相关的不良事件。本研究纳入了68例食用煮小龙虾后患上哈夫病的患者。除了哈夫病的标准治疗外，22例患者在入院12小时内口服了活性炭和甘露醇（ACM组），而其他46例患者未接受此类治疗（非ACM组）。两组之间的基线特征，包括临床症状、血清酶水平和疼痛/焦虑评分具有可比性。活性炭和甘露醇治疗使住院后12小时至60小时的肌酸激酶同工酶（CK-MB）和天门冬氨酸氨基转移酶（AST）水平降低，12小时至72小时的丙氨酸氨基转移酶（ALT）和乳酸脱氢酶（LDH）水平降低，24小时至72小时的肌酸激酶（CK）水平降低。ACM组患者的住院时间明显缩短（7.5[6.0 - 8.0]天 vs 8.0[6.8 - 10.0]天，P = 0.032），且入院24小时后的焦虑评分低于非ACM组（40.7±4.9 vs 44.1±6.3，P = 0.032）。没有患者经历与治疗相关的不良事件。两组的总体预后良好。在由煮小龙虾引起的哈夫病患者中，活性炭联合甘露醇治疗可缩短住院时间，降低血清CK、CK-MB、AST、ALT和LDH水平，并降低焦虑评分。
