Yusni Yusni, Meutia Firdalena
Department of Physiology, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, Aceh, Indonesia.
Department of Pharmacology, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, Aceh, Indonesia.
Evid Based Complement Alternat Med. 2020 Sep 14;2020:5351318. doi: 10.1155/2020/5351318. eCollection 2020.
Rosella is a safe medicinal herb used by people in Indonesia. They believe that rosella is effective in controlling metabolic syndrome, working with antihypertension, antidiabetic, antidyslipidemia and antiobesity effects. The purpose of this study was to determine the effect of rosella in controlling metabolic syndrome through the secretion of blood nitric oxide (NO) and the cortisol pathway.
This study was a quasiexperimental, pretest-posttest with control group design. The total subjects were 18 people, women, and the elderly. Subjects were selected randomly into 2 groups: control group ( = 8) and treatment group ( = 8). The treatment was rosella tea, a dose of 2 grams, duration 2 times a day, given in the morning (08.00-8.30 a.m.) and evening (06.30-7.00 p.m.) after meals for 21 days. Examination of NO and cortisol levels was carried out using the enzyme-linked immunosorbent assay (ELISA) method.
There was a significant decrease in bodyweight (BW) ( = 0.021), systolic blood pressure (SBP) ( = 0.001), diastolic blood pressure (DBP) ( = 0.049), glucose preprandial (FPG) ( = 0.014), total cholesterol (CT) ( = 0.001), triglycerides (TGs) ( = 0.014), high-density lipoprotein (HDL) ( = 0.001), and low-density lipoprotein (LDL) ( = 0.010) after consuming rosella. NO levels were significantly increased ( = 0.012), whereas cortisol levels decreased significantly ( = 0.008) after therapy with rosella tea in elderly women.
Rosella has shown evidence to control and lower blood pressure, blood glucose, lipid profile, and cortisol in the elderly with metabolic syndrome. Rosella is a traditional medicine that has the potential to be developed as a therapy for metabolic syndrome patients.
玫瑰茄是印度尼西亚人使用的一种安全药草。他们认为玫瑰茄在控制代谢综合征方面有效，具有抗高血压、抗糖尿病、抗血脂异常和抗肥胖作用。本研究的目的是通过血液一氧化氮（NO）分泌和皮质醇途径来确定玫瑰茄在控制代谢综合征方面的作用。
本研究为类实验性、有对照组的前后测设计。总共有18名女性老年人作为研究对象。将研究对象随机分为两组：对照组（n = 8）和治疗组（n = 8）。治疗方法是饮用玫瑰茄茶，剂量为2克，每天2次，于早餐后（上午08:00 - 8:30）和晚餐后（下午06:30 - 7:00）服用，持续21天。采用酶联免疫吸附测定（ELISA）法检测NO和皮质醇水平。
饮用玫瑰茄后，体重（BW）（P = 0.021）、收缩压（SBP）（P = 0.001）、舒张压（DBP）（P = 0.049）、空腹血糖（FPG）（P = 0.014）、总胆固醇（CT）（P = 0.001）、甘油三酯（TGs）（P = 0.014）、高密度脂蛋白（HDL）（P = 0.001）和低密度脂蛋白（LDL）（P = 0.010）均显著下降。老年女性饮用玫瑰茄茶治疗后，NO水平显著升高（P = 0.012），而皮质醇水平显著降低（P = 0.008）。
玫瑰茄已显示出对患有代谢综合征的老年人控制和降低血压、血糖、血脂水平及皮质醇的作用。玫瑰茄是一种有潜力被开发用于治疗代谢综合征患者的传统药物。
