Diantini Ajeng, Rahmat Syamsul, Alpiani Annisa, Sumiwi Sri Adi, Lubis Leonardo, Levita Jutti
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, West Java 45363, Indonesia.
Faculty of Health, Universitas Qamarul Huda Badaruddin Bagu, Central Lombok Regency, West Nusa Tenggara 83371, Indonesia.
Biomed Rep. 2021 Nov;15(5):89. doi: 10.3892/br.2021.1465. Epub 2021 Aug 26.
The calyx of roselle ( L.) has been the focus of attention of several studies, and although earlier studies on this plant showed it to possess antilipidemic and antidiabetic activities, none of these studies have assessed the effects of this plant on the physiological parameters of healthy subjects. The present study determined the effects of roselle calyx beverages on blood pressure, abdominal circumference, body mass index (BMI), hematological and urinary parameters, and the lipid profile of healthy subjects. Healthy subjects (n=30) were treated with a 200 ml roselle calyx beverage each morning and evening for 30 consecutive days. Every week the subjects were asked to perform some physical activity by following the Young Men's Christian Association step test. This study used a pre-post quasi-experimental design. Blood samples were taken before (day-0) and after the intervention (day-30). There was an increase in the levels of high-density lipoproteins (from 47.0 to 49.5 mg/dl; P=0.015), and a significant decrease in both systolic and diastolic (P=0.036 and P=0.030, respectively), and the abdominal circumference of the subjects (P=0.005). However, total cholesterol levels (191.2 to 191.9 mg/dl; P=0.821) and low-density lipoprotein levels (129.8 to 133.5 mg/dl; P=0.249) were slightly increased, although not significantly. A lower level of triglycerides (114.3 to 107.4 mg/dl; P=0.269) and very-low-density lipoprotein levels (22.8 to 21.4 mg/dl; P=0.681) was observed. No significant differences were detected in the BMI or the urinalysis parameters were identified. Based on these results, roselle ( L.) may be used as a supplement to prospectively improve the health status of subjects. No serious adverse effects were observed during this trial.
玫瑰茄(L.)的花萼一直是多项研究的关注焦点,尽管早期对这种植物的研究表明它具有抗血脂和抗糖尿病活性,但这些研究均未评估该植物对健康受试者生理参数的影响。本研究确定了玫瑰茄花萼饮料对健康受试者的血压、腹围、体重指数(BMI)、血液学和尿液参数以及血脂谱的影响。30名健康受试者连续30天每天早晚各饮用200毫升玫瑰茄花萼饮料。每周要求受试者按照基督教青年会台阶测试进行一些体育活动。本研究采用前后准实验设计。在干预前(第0天)和干预后(第30天)采集血样。高密度脂蛋白水平有所升高(从47.0毫克/分升降至49.5毫克/分升;P = 0.015),受试者的收缩压和舒张压均显著降低(分别为P = 0.036和P = 0.030),腹围也显著减小(P = 0.005)。然而,总胆固醇水平(从191.2毫克/分升降至191.9毫克/分升;P = 0.821)和低密度脂蛋白水平(从129.8毫克/分升降至133.5毫克/分升;P = 0.249)虽略有升高,但不显著。观察到甘油三酯水平较低(从114.3毫克/分升降至107.4毫克/分升;P = 0.269)以及极低密度脂蛋白水平较低(从22.8毫克/分升降至21.4毫克/分升;P = 0.681)。在BMI或尿液分析参数方面未检测到显著差异。基于这些结果,玫瑰茄(L.)可作为一种补充剂,有望改善受试者的健康状况。在该试验期间未观察到严重不良反应。