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头孢他啶在接受心脏直视手术患者的心脏瓣膜、皮下及肌肉组织中的渗透情况。

Penetration of ceftazidime into heart valves and subcutaneous and muscle tissue of patients undergoing open-heart surgery.

作者信息

Frank U, Kappstein I, Schmidt-Eisenlohr E, Schlosser V, Spillner G, Schindler M, Daschner F D

出版信息

Antimicrob Agents Chemother. 1987 May;31(5):813-4. doi: 10.1128/AAC.31.5.813.

DOI:10.1128/AAC.31.5.813
PMID:3300542
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC174840/
Abstract

Patients undergoing open-heart surgery were given an intravenous bolus injection of 2 g of ceftazidime as a single dose over a period of 5 min. Within 12 h, ceftazidime concentrations in serum declined from 55.8 to 3.9 mg/liter. Subcutaneous tissue concentrations of the drug decreased from 21.0 to 2.7 micrograms/g, and muscle concentrations decreased from 34.5 to 2.5 micrograms/g. Ceftazidime concentrations in cardiac valvular tissue were even higher than those in muscle or fat, declining from 37.4 to 6.3 micrograms/g within 10 h.

摘要

接受心脏直视手术的患者静脉推注2克头孢他啶，单次剂量，持续5分钟。12小时内，血清中头孢他啶浓度从55.8毫克/升降至3.9毫克/升。药物在皮下组织中的浓度从21.0微克/克降至2.7微克/克，肌肉中的浓度从34.5微克/克降至2.5微克/克。心脏瓣膜组织中的头孢他啶浓度甚至高于肌肉或脂肪中的浓度，10小时内从37.4微克/克降至6.3微克/克。

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本文引用的文献

1
Stomaching: a new concept in bacteriological sample preparation.胃孵育法：细菌学样本制备中的一个新概念。
Appl Microbiol. 1972 Aug;24(2):175-8. doi: 10.1128/am.24.2.175-178.1972.
2
The pharmacokinetic behaviour of ceftazidime in man and the relationship between serum levels and the in vitro susceptibility of clinical isolates.头孢他啶在人体内的药代动力学行为以及血清水平与临床分离株体外敏感性之间的关系。
Infection. 1983;11 Suppl 1:S49-53. doi: 10.1007/BF01641107.
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Simplified, accurate method for antibiotic assay of clinical specimens.临床标本抗生素检测的简化、准确方法。
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Clinical pharmacokinetics of the third generation cephalosporins.第三代头孢菌素的临床药代动力学
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Ceftazidime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.头孢他啶。对其抗菌活性、药代动力学特性及治疗用途的综述。
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