头孢他啶在接受心脏直视手术患者的心脏瓣膜、皮下及肌肉组织中的渗透情况。
Penetration of ceftazidime into heart valves and subcutaneous and muscle tissue of patients undergoing open-heart surgery.
作者信息
Frank U, Kappstein I, Schmidt-Eisenlohr E, Schlosser V, Spillner G, Schindler M, Daschner F D
出版信息
Antimicrob Agents Chemother. 1987 May;31(5):813-4. doi: 10.1128/AAC.31.5.813.
Abstract
Patients undergoing open-heart surgery were given an intravenous bolus injection of 2 g of ceftazidime as a single dose over a period of 5 min. Within 12 h, ceftazidime concentrations in serum declined from 55.8 to 3.9 mg/liter. Subcutaneous tissue concentrations of the drug decreased from 21.0 to 2.7 micrograms/g, and muscle concentrations decreased from 34.5 to 2.5 micrograms/g. Ceftazidime concentrations in cardiac valvular tissue were even higher than those in muscle or fat, declining from 37.4 to 6.3 micrograms/g within 10 h.
摘要
接受心脏直视手术的患者静脉推注2克头孢他啶，单次剂量，持续5分钟。12小时内，血清中头孢他啶浓度从55.8毫克/升降至3.9毫克/升。药物在皮下组织中的浓度从21.0微克/克降至2.7微克/克，肌肉中的浓度从34.5微克/克降至2.5微克/克。心脏瓣膜组织中的头孢他啶浓度甚至高于肌肉或脂肪中的浓度，10小时内从37.4微克/克降至6.3微克/克。
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