Adam D, Reichart B, Williams K J
J Antimicrob Chemother. 1983 Jul;12 Suppl A:269-73. doi: 10.1093/jac/12.suppl_a.269.
The penetration of ceftazidime into human heart muscle, skeletal muscle, skin, fat and bone was measured in 39 patients undergoing cardiac surgery. Mean serum levels of 70 mg/l were measured 1.5 h after dosing with mean levels of 27 mg/l after 4 h and 5.5 mg/l after 12 h. Tissue levels of ceftazidime were measured up to 280 min after dosing. These levels were high with mean corrected levels after 120 min of 20.0 mg/l in bone, 7.1 mg/l in skin (after 100 min), 9.2 mg/l in fat, 12.7 mg/l in heart muscle and 9.4 mg/l in skeletal muscle. Serum and tissue levels were sufficient to prevent infection by all likely pathogens, including Staphylococcus aureus, 98% of which have a ceftazidime minimum inhibitory concentration of 8 mg/l or less. There were no post-surgical infections.
在39例接受心脏手术的患者中，测定了头孢他啶在人心脏肌肉、骨骼肌、皮肤、脂肪和骨骼中的渗透情况。给药后1.5小时测得平均血清水平为70mg/L，4小时后平均水平为27mg/L，12小时后为5.5mg/L。在给药后长达280分钟的时间里测定了头孢他啶的组织水平。这些水平较高，120分钟后骨组织中平均校正水平为20.0mg/L，皮肤中为7.1mg/L（100分钟后），脂肪中为9.2mg/L，心脏肌肉中为12.7mg/L，骨骼肌中为9.4mg/L。血清和组织水平足以预防包括金黄色葡萄球菌在内的所有可能病原体的感染，其中98%的金黄色葡萄球菌对头孢他啶的最低抑菌浓度为8mg/L或更低。术后无感染发生。
