Just H M, Bassler M, Frank U, Spillner G, Schlosser V, Daschner F
J Antimicrob Chemother. 1984 Oct;14(4):431-4. doi: 10.1093/jac/14.4.431.
Twenty-nine adult patients undergoing open-heart surgery were given 2 g cefotaxime as 5 min intravenous bolus injection preoperatively. Within 6 h cefotaxime serum concentrations declined from 81.0 to 6.3 mg/l. Subcutaneous tissue and muscle concentrations varied between 0.3 and 8.7 micrograms/g, heart valve concentrations varied between 2.2 and 13.0 micrograms/g. Cefotaxime concentrations in heart valves are high enough to inhibit most Gram-negative organisms causing postoperative wound infections and endocarditis.
29例接受心脏直视手术的成年患者在术前5分钟静脉推注2克头孢噻肟。6小时内，头孢噻肟血清浓度从81.0毫克/升降至6.3毫克/升。皮下组织和肌肉浓度在0.3至8.7微克/克之间变化，心脏瓣膜浓度在2.2至13.0微克/克之间变化。心脏瓣膜中的头孢噻肟浓度足以抑制大多数引起术后伤口感染和心内膜炎的革兰氏阴性菌。
