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接受心脏直视手术患者心脏瓣膜、皮下组织及肌肉组织中氟氯西林的浓度。

Concentrations of flucloxacillin in heart valves and subcutaneous and muscle tissues of patients undergoing open-heart surgery.

作者信息

Frank U, Schmidt-Eisenlohr E, Schlosser V, Spillner G, Schindler M, Daschner F D

机构信息

Department of Hospital Epidemiology, University Hospital, Freiburg, Federal Republic of Germany.

出版信息

Antimicrob Agents Chemother. 1988 Jun;32(6):930-1. doi: 10.1128/AAC.32.6.930.

DOI:10.1128/AAC.32.6.930
PMID:3415213
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC172310/
Abstract

Thirty-seven patients were given a single, 2-g intravenous bolus injection of flucloxacillin prior to open-heart surgery. Within 12 h, flucloxacillin concentrations in serum and heart valves declined from 125.2 to 4.4 micrograms/ml and from 16.5 to 3.7 micrograms/g, respectively. Concentrations in subcutaneous tissue and muscle were almost identical, declining from 14.7 or 14.2 micrograms/g to undetectable levels after 8 to 10 h.

摘要

37名患者在心脏直视手术前接受了单次2克静脉注射氟氯西林。在12小时内，血清和心脏瓣膜中的氟氯西林浓度分别从125.2微克/毫升降至4.4微克/毫升，从16.5微克/克降至3.7微克/克。皮下组织和肌肉中的浓度几乎相同，在8至10小时后从14.7或14.2微克/克降至无法检测的水平。

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Concentrations of flucloxacillin in heart valves and subcutaneous and muscle tissues of patients undergoing open-heart surgery.接受心脏直视手术患者心脏瓣膜、皮下组织及肌肉组织中氟氯西林的浓度。
Antimicrob Agents Chemother. 1988 Jun;32(6):930-1. doi: 10.1128/AAC.32.6.930.
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本文引用的文献

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Stomaching: a new concept in bacteriological sample preparation.胃孵育法：细菌学样本制备中的一个新概念。
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Extravascular penetration of highly protein-bound flucloxacillin.高蛋白结合率氟氯西林的血管外渗透
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Pharmacokinetics of vancomycin in serum and tissue of patients undergoing open-heart surgery.
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Penetration of ceftazidime into heart valves and subcutaneous and muscle tissue of patients undergoing open-heart surgery.头孢他啶在接受心脏直视手术患者的心脏瓣膜、皮下及肌肉组织中的渗透情况。
Antimicrob Agents Chemother. 1987 May;31(5):813-4. doi: 10.1128/AAC.31.5.813.