接受心脏直视手术患者心脏瓣膜、皮下组织及肌肉组织中氟氯西林的浓度。
Concentrations of flucloxacillin in heart valves and subcutaneous and muscle tissues of patients undergoing open-heart surgery.
作者信息
Frank U, Schmidt-Eisenlohr E, Schlosser V, Spillner G, Schindler M, Daschner F D
机构信息
Department of Hospital Epidemiology, University Hospital, Freiburg, Federal Republic of Germany.
出版信息
Antimicrob Agents Chemother. 1988 Jun;32(6):930-1. doi: 10.1128/AAC.32.6.930.
Abstract
Thirty-seven patients were given a single, 2-g intravenous bolus injection of flucloxacillin prior to open-heart surgery. Within 12 h, flucloxacillin concentrations in serum and heart valves declined from 125.2 to 4.4 micrograms/ml and from 16.5 to 3.7 micrograms/g, respectively. Concentrations in subcutaneous tissue and muscle were almost identical, declining from 14.7 or 14.2 micrograms/g to undetectable levels after 8 to 10 h.
摘要
37名患者在心脏直视手术前接受了单次2克静脉注射氟氯西林。在12小时内，血清和心脏瓣膜中的氟氯西林浓度分别从125.2微克/毫升降至4.4微克/毫升，从16.5微克/克降至3.7微克/克。皮下组织和肌肉中的浓度几乎相同，在8至10小时后从14.7或14.2微克/克降至无法检测的水平。
相似文献
1
Concentrations of flucloxacillin in heart valves and subcutaneous and muscle tissues of patients undergoing open-heart surgery.接受心脏直视手术患者心脏瓣膜、皮下组织及肌肉组织中氟氯西林的浓度。
Antimicrob Agents Chemother. 1988 Jun;32(6):930-1. doi: 10.1128/AAC.32.6.930.
2
Penetration of ceftazidime into heart valves and subcutaneous and muscle tissue of patients undergoing open-heart surgery.头孢他啶在接受心脏直视手术患者的心脏瓣膜、皮下及肌肉组织中的渗透情况。
Antimicrob Agents Chemother. 1987 May;31(5):813-4. doi: 10.1128/AAC.31.5.813.
3
Penetration of cefotaxime into heart valves, subcutaneous and muscle tissue of patients undergoing open-heart surgery.头孢噻肟在接受心脏直视手术患者的心脏瓣膜、皮下及肌肉组织中的渗透情况。
J Antimicrob Chemother. 1984 Oct;14(4):431-4. doi: 10.1093/jac/14.4.431.
4
[Concentrations of cefotiam in serum, heart valves, muscle and adipose tissue during heart surgery].心脏手术期间血清、心脏瓣膜、肌肉和脂肪组织中头孢替安的浓度
Arzneimittelforschung. 1983;33(4):578-9.
5
Concentrations of mezlocillin in the serum, heart valves, muscle and subcutaneous tissue of patients undergoing open-heart surgery.接受心脏直视手术患者血清、心脏瓣膜、肌肉及皮下组织中美洛西林的浓度。
Infection. 1985 Jul-Aug;13(4):182-3. doi: 10.1007/BF01642809.
6
Plasma, bone, hip capsule and drain fluid concentrations of ampicillin and flucloxacillin during total hip replacement after intravenous bolus injection of magnapen.静脉推注美洛培南后全髋关节置换术中氨苄西林和氟氯西林的血浆、骨、髋关节囊及引流液浓度。
Br J Clin Pharmacol. 1978 Aug;6(2):135-43. doi: 10.1111/j.1365-2125.1978.tb00838.x.
7
The penetration of flucloxacillin into cortical and cancellous bone during arthroplasty of the knee.
Int Orthop. 1982;6(4):243-7. doi: 10.1007/BF00267145.
8
Flucloxacillin in bone.氟氯西林在骨骼中的情况。
J Clin Pathol. 1978 Aug;31(8):705-11. doi: 10.1136/jcp.31.8.705.
9
Investigations on the flucloxacillin levels in human serum, lung tissue, pericardial fluid and heart tissue.
Int J Clin Pharmacol Ther Toxicol. 1980 Sep;18(9):405-11.
10
Bioavailability and half-life of two preparations of flucloxacillin.
N Z Med J. 1982 Nov 10;95(719):766-8.
引用本文的文献
1
Pharmacodynamics of Flucloxacillin in a Neutropenic Murine Thigh Infection Model: A Piece of the Puzzle towards Evidence-Based Dosing.氟氯西林在中性粒细胞减少小鼠大腿感染模型中的药效学：迈向循证给药的关键一环
Antibiotics (Basel). 2022 Aug 3;11(8):1049. doi: 10.3390/antibiotics11081049.
2
In vivo effect of flucloxacillin in experimental endocarditis caused by mecC-positive staphylococcus aureus showing temperature-dependent susceptibility in vitro.氟氯西林在体外表现出温度依赖性敏感性的mecC阳性金黄色葡萄球菌所致实验性心内膜炎中的体内作用
Antimicrob Agents Chemother. 2015 Apr;59(4):2435-8. doi: 10.1128/AAC.04733-14. Epub 2015 Jan 20.
3
Penetration of teicoplanin into heart valves and subcutaneous and muscle tissues of patients undergoing open-heart surgery.替考拉宁在心脏直视手术患者心脏瓣膜、皮下及肌肉组织中的渗透情况。
Antimicrob Agents Chemother. 1997 Nov;41(11):2559-61. doi: 10.1128/AAC.41.11.2559.
4
Levofloxacin versus ciprofloxacin, flucloxacillin, or vancomycin for treatment of experimental endocarditis due to methicillin-susceptible or -resistant Staphylococcus aureus.左氧氟沙星与环丙沙星、氟氯西林或万古霉素治疗甲氧西林敏感或耐药金黄色葡萄球菌所致实验性心内膜炎的疗效比较
Antimicrob Agents Chemother. 1997 Aug;41(8):1662-7. doi: 10.1128/AAC.41.8.1662.
本文引用的文献
1
Stomaching: a new concept in bacteriological sample preparation.胃孵育法：细菌学样本制备中的一个新概念。
Appl Microbiol. 1972 Aug;24(2):175-8. doi: 10.1128/am.24.2.175-178.1972.
2
Flucloxacillin, a new isoxazolyl penicillin, compared with oxacillin, cloxacillin, and dicloxacillin.氟氯西林，一种新型异恶唑基青霉素，与苯唑西林、氯唑西林和双氯西林进行比较。
Br Med J. 1970 Nov 21;4(5733):455-60. doi: 10.1136/bmj.4.5733.455.
3
Simplified, accurate method for antibiotic assay of clinical specimens.临床标本抗生素检测的简化、准确方法。
Appl Microbiol. 1966 Mar;14(2):170-7. doi: 10.1128/am.14.2.170-177.1966.
4
Flucloxacillin concentration in serum and wound exudate during open heart surgery.心脏直视手术期间血清和伤口渗出液中的氟氯西林浓度。
J Antimicrob Chemother. 1985 Aug;16(2):253-9. doi: 10.1093/jac/16.2.253.
5
Extravascular penetration of highly protein-bound flucloxacillin.高蛋白结合率氟氯西林的血管外渗透
Antimicrob Agents Chemother. 1986 Nov;30(5):729-32. doi: 10.1128/AAC.30.5.729.
6
Pharmacokinetics of vancomycin in serum and tissue of patients undergoing open-heart surgery.
J Antimicrob Chemother. 1987 Mar;19(3):359-62. doi: 10.1093/jac/19.3.359.
7
Penetration of ceftazidime into heart valves and subcutaneous and muscle tissue of patients undergoing open-heart surgery.头孢他啶在接受心脏直视手术患者的心脏瓣膜、皮下及肌肉组织中的渗透情况。
Antimicrob Agents Chemother. 1987 May;31(5):813-4. doi: 10.1128/AAC.31.5.813.
Zotero 插件