Tarsariya Vivek M, Mehta Dhaval N, Raval Nilesh, Patadiya Hiren H, Vachhrajani Kanan, Ashem Albert
Shantabaa Medical College & General Hospital, Amreli, Gujarat, India.
Dept. of Oral Medicine & Radiology, Narsinhbhai Patel Dental College & Hospital, Visnagar, Gujarat, India.
J Oral Biol Craniofac Res. 2020 Oct-Dec;10(4):665-669. doi: 10.1016/j.jobcr.2020.09.002. Epub 2020 Sep 8.
Only few studies have been done to evaluate level of serum immunoglobulins (IgG,IgM,IgA) in patients with Potentially Malignant Disorders (PMD) like Leukoplakia, Oral Submucous Fibrosis (OSMF) and Oral Lichen Planus (OLP) as tumour markers.
To estimate the serum immunoglobulins level (IgG, IgM, IgA) in leukoplakia, OSMF and oral lichen planus (OLP) patients and its comparison with levels among control groups and Weather these values can be used to predict severity of disease or not.
30 patients with different potentially malignant disorders like leukoplakia, OSMF and oral lichen planus and 30 healthy controls were selected at random and subjected for analysis of serum IgG, IgA, IgM. Statistical methods employed were mean, standard deviation and ANOVA test.
We observed significant elevated levels of all the immunoglobulins in leukoplakia, OSMF and oral lichen planus when compared with the control group and levels were increasing with clinical stages of OSMF
All these immunoglobulins are indicative of tumour burden or transformation of malignancy in higher stage and might be employed as prognostic indicators in these disorders.
仅有少数研究评估过如白斑、口腔黏膜下纤维化（OSMF）和口腔扁平苔藓（OLP）等潜在恶性疾病（PMD）患者血清免疫球蛋白（IgG、IgM、IgA）水平作为肿瘤标志物的情况。
评估白斑、OSMF和口腔扁平苔藓（OLP）患者的血清免疫球蛋白水平（IgG、IgM、IgA），并与对照组水平进行比较，以及这些值是否可用于预测疾病严重程度。
随机选取30例患有不同潜在恶性疾病（如白斑、OSMF和口腔扁平苔藓）的患者以及30例健康对照，进行血清IgG、IgA、IgM分析。采用的统计方法有均值、标准差和方差分析测试。
我们观察到，与对照组相比，白斑、OSMF和口腔扁平苔藓患者所有免疫球蛋白水平均显著升高，且OSMF的水平随临床分期增加。
所有这些免疫球蛋白均表明肿瘤负荷或晚期恶性转化，可能作为这些疾病的预后指标。
