Swami Anand N, Kale Lata M, Choudhary Sneha H, Singh Ashok Kumar, Aldhuwayhi Sami D, Thakare Amar
Swami Multispeciality Dental Clinic, Osmanabad, Maharashtra, India.
Department of Oral Medicine and Radiology, C.S.M.S.S. Dental College and Hospital, Aurangabad, Maharashtra, India.
Natl J Maxillofac Surg. 2022 Jan-Apr;13(1):67-71. doi: 10.4103/njms.NJMS_238_20. Epub 2022 Apr 20.
Oral submucous fibrosis (OSMF) is a disabling, chronic, insidious potentially malignant condition of the oral cavity seen predominantly in the Indian subcontinent. Due to the idiopathic nature and various immunological changes seen in some OSMF patients, it can be considered an autoimmune disorder. Hyperimmunoglobulinemia is often seen with OSMF.
(i) To estimate the serum immunoglobulin G (IgG) and immunoglobulin A (IgA) levels in OSMF patients; (ii) to correlate the serum IgG and IgA levels with age and gender of OSMF patients; (iii) to correlate the serum IgG and IgA levels with clinical stages of OSMF; (iv) to correlate the serum IgG and IgA levels with the content of the habit in OSMF patients.
Serum samples were collected from a total of 50 patients (25 OSMF cases and 25 controls) of both genders and IgG and IgA levels were estimated by NEPHELOMETRY.
As compared to the control group, the mean serum IgG level was marginally increased among the OSMF patients and the mean serum IgA level was marginally decreased among the OSMF patients, but this was not statistically significant. Furthermore, there was only a weak correlation between serum immunoglobulins and content of the habit and no significant correlation was found between the serum IgG and IgA levels and age and sex of the OSMF patients. Serum IgG was increased and IgA was decreased with increasing stages of OSMF.
The results of the present study suggested that there is an alteration in serum immunoglobulin levels in OSMF patients as compared to the control group.
口腔黏膜下纤维化（OSMF）是一种致残性、慢性、隐匿性的口腔潜在恶性疾病，主要见于印度次大陆。由于其特发性本质以及在一些OSMF患者中观察到的各种免疫变化，它可被视为一种自身免疫性疾病。OSMF患者常出现高免疫球蛋白血症。
（i）评估OSMF患者血清免疫球蛋白G（IgG）和免疫球蛋白A（IgA）水平；（ii）将血清IgG和IgA水平与OSMF患者的年龄和性别相关联；（iii）将血清IgG和IgA水平与OSMF的临床分期相关联；（iv）将血清IgG和IgA水平与OSMF患者的习惯内容相关联。
收集了共50例患者（25例OSMF病例和25例对照）的血清样本，样本来自不同性别的患者，并通过比浊法评估IgG和IgA水平。
与对照组相比，OSMF患者的平均血清IgG水平略有升高，而OSMF患者的平均血清IgA水平略有降低，但这在统计学上无显著意义。此外，血清免疫球蛋白与习惯内容之间仅存在弱相关性，且未发现血清IgG和IgA水平与OSMF患者的年龄和性别之间存在显著相关性。随着OSMF分期的增加，血清IgG升高而IgA降低。
本研究结果表明，与对照组相比，OSMF患者的血清免疫球蛋白水平存在改变。
