Tariq Mehak, Jalli Vishwanath V, Dhurubatha J, Medhi Reeturaj, Malawat Kanchan, Gowdar Inderjit M, Arya Sugandha
Department of Oral Medicine and Radiology, Srinagar, Jammu and Kashmir, India.
Department of Oral Medicine and Radiology, Government Dental College and Research Institute, VIMS, Cantonment, Ballari, Karnataka, India.
J Pharm Bioallied Sci. 2024 Feb;16(Suppl 1):S570-S573. doi: 10.4103/jpbs.jpbs_868_23. Epub 2023 Dec 20.
The aim of the study is to compare the clinical efficacy of both the topical agents-aloe vera gel and Kenacort oral paste (0.1% triamcinolone acetonide) in patients with minor aphthous stomatitis.
60 patients were recruited for the study and were randomly divided into two groups-Group A (aloe vera gel group) and Group B (Kenacort oral paste group). The baseline parameters were taken and recorded on the day of the first visit which included ulcer size, pain, and burning sensation. Evaluation of reduction in ulcer size, pain, and burning sensation were made on day 3 and day 7.
The results of the present study revealed that both the study groups showed no significant difference in the size of ulcer at day 1, day 3, and day 7 when compared using independent -test as > 0.05 at all study intervals. Therefore, both the agents were found to be equally effective against reducing the size of ulcer, pain, and burning sensation.
The present study findings demonstrate that topical application of the aloe vera gel was able to decrease the ulcer size, intensity of pain, and burning sensation, thereby accelerating the healing without any side effects. Thus, topical aloe vera could be safe and a better alternative to topical steroid for RAS.
本研究旨在比较局部用药——芦荟凝胶和曲安奈德口腔糊剂（0.1%曲安奈德）治疗轻型复发性阿弗他溃疡患者的临床疗效。
招募60例患者参与本研究，并随机分为两组——A组（芦荟凝胶组）和B组（曲安奈德口腔糊剂组）。在首次就诊当天记录基线参数，包括溃疡大小、疼痛和烧灼感。在第3天和第7天评估溃疡大小、疼痛和烧灼感的减轻情况。
本研究结果显示，使用独立样本t检验比较时，两个研究组在第1天、第3天和第7天的溃疡大小均无显著差异，所有研究时间段的P值均>0.05。因此，发现两种药物在减小溃疡大小、疼痛和烧灼感方面同样有效。
本研究结果表明，局部应用芦荟凝胶能够减小溃疡大小、减轻疼痛强度和烧灼感，从而加速愈合且无任何副作用。因此，局部应用芦荟对于复发性阿弗他溃疡可能是安全且优于局部用类固醇的更好选择。
