Chen Haolin, Liu Zhiming, Wei Bo, Huang Jun, You Xinru, Zhang Jingyang, Yuan Zhiling, Tang Zhilie, Guo Zhouyi, Wu Jun
Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Sun Yat-sen University, Guangzhou, 510006, China.
MOE Key Laboratory of Laser Life Science & SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology, College of Biophotonics, South China Normal University, Guangzhou, 510631, China.
Bioact Mater. 2020 Sep 21;6(3):655-665. doi: 10.1016/j.bioactmat.2020.08.034. eCollection 2021 Mar.
Effective cancer treatment puts high demands for cancer theranostics. For cancer diagnostics, optical coherence tomography (OCT) technology (including photothermal optical coherence tomography (PT-OCT)) has been widely investigated since it induces changes in optical phase transitions in tissue through environmental changes (such as temperature change for PT-OCT). In this report, redox responsive nanoparticle encapsulating black phosphorus quantum dots was developed as a robust PT-OCT agent. Briefly, black phosphorus quantum dots (BPQDs) are incorporated into cysteine-based poly-(disulfide amide) (Cys-PDSA) to form stable and biodegradable nanoagent. The excellent photothermal feature allows BPQD/Cys-PDSA nanoparticles (NPs) as a novel contrast agent for high-resolution PT-OCT bioimaging. The Cys-PDSA can rapidly respond to glutathione and effectively release BPQDs and drugs and . And the obtained NPs exhibit excellent near-infrared (NIR) photothermal transduction efficiency and drug delivery capacity that can serve as novel therapeutic platform, with very low chemo drug dosage and side effects. Both of the polymer and BPQD are degradable, indicating this platform is a rare PT-OCT agent that is completely biodegradable. Overall, our research highlights a biodegradable and biocompatible black phosphorus-based nanoagent for both cancer diagnosis and therapy.
有效的癌症治疗对癌症诊疗技术提出了很高的要求。对于癌症诊断，光学相干断层扫描（OCT）技术（包括光热光学相干断层扫描（PT-OCT））已得到广泛研究，因为它通过环境变化（如PT-OCT中的温度变化）诱导组织中光学相变的变化。在本报告中，开发了一种包裹黑磷量子点的氧化还原响应纳米颗粒作为一种强大的PT-OCT试剂。简而言之，将黑磷量子点（BPQDs）掺入基于半胱氨酸的聚（二硫酰胺）（Cys-PDSA）中，形成稳定且可生物降解的纳米试剂。优异的光热特性使BPQD/Cys-PDSA纳米颗粒（NPs）成为用于高分辨率PT-OCT生物成像的新型造影剂。Cys-PDSA可以快速响应谷胱甘肽并有效释放BPQDs和药物。并且所获得的纳米颗粒表现出优异的近红外（NIR）光热转导效率和药物递送能力，可作为新型治疗平台，化疗药物剂量非常低且副作用小。聚合物和BPQD均可降解，表明该平台是一种罕见的完全可生物降解的PT-OCT试剂。总体而言，我们的研究突出了一种用于癌症诊断和治疗的可生物降解且生物相容的基于黑磷的纳米试剂。
