Programa de Pós-Graduação em Ciências e Biotecnologia, Universidade Federal Fluminense (UFF), Niterói, Brazil.
Hospital Universitário Antônio Pedro, Universidade Federal Fluminense (UFF), Niterói, Brazil.
Inhal Toxicol. 2020 Aug;32(9-10):375-387. doi: 10.1080/08958378.2020.1825569. Epub 2020 Oct 2.
Silicosis is a lung disease of fibrotic nature resulting from the inhalation and deposition of dust containing crystalline silica. Subjects exposed to the same environmental factors may show distinct radiological manifestations, and since silicosis is known as a multifactorial disease, it is plausible that individual genetic susceptibility may play a role in the pathology. This review of the literature aims to provide an assessment of the present data on the genetic association studies in silicosis and describe the genes that potentially might influence silicosis susceptibility in silica-exposed individuals.
We accessed the database of PubMed for articles published in English about interindividual genetic susceptibility to silicosis using terms related to the subject matter.
Following the evaluation process, 28 studies were included in this systematic review, including 23 original studies and 5 meta-analyses.
Regardless of the advances in the knowledge of the importance of gene variations in silicosis, more studies need to be performed, in particular, special polygenic and genome-wide investigations.
矽肺是一种纤维化性质的肺部疾病，由吸入和沉积含结晶二氧化硅的粉尘引起。暴露于相同环境因素的个体可能表现出不同的放射学表现，由于矽肺被认为是一种多因素疾病，因此个体遗传易感性可能在发病机制中起作用。本文对文献进行综述，旨在评估矽肺遗传相关性研究的现有数据，并描述可能影响暴露于二氧化硅的个体发生矽肺易感性的潜在基因。
我们使用与主题相关的术语检索了 PubMed 数据库中发表的关于个体对矽肺遗传易感性的英文文章。
经过评估过程，本系统综述纳入了 28 项研究，包括 23 项原始研究和 5 项荟萃分析。
尽管人们越来越认识到基因变异在矽肺中的重要性，但仍需要开展更多的研究，特别是特殊的多基因和全基因组研究。
