Department of Internal Medicine, Hazrat-E-Rasool General Hospital, Tehran, Iran.
Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Inflammopharmacology. 2020 Dec;28(6):1421-1438. doi: 10.1007/s10787-020-00762-y. Epub 2020 Oct 2.
Innate immunity refers to defense mechanisms that are always present, ready to combat microbes and other offending agents. Innate immunity acts as a first-line defense and activates the conventional immune responses; however, it has been speculated that the importance of innate immunity in initiation and development of some disorders is more than just the "first line of defense". Autoimmune diseases, caused by immune system overactivation, are among the most challenging scientific and clinical problems, and there is still much to be learned about their pathogenesis. We aimed to provide a comprehensive overview of available documents about the role of innate immunity in systemic autoimmune diseases including rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, polymyositis, and systemic sclerosis. This study highlights the innate immunity pathways or molecules that are under investigation for therapy of these diseases.
先天免疫是指始终存在的防御机制，随时准备抵御微生物和其他致病因子。先天免疫作为第一道防线，激活常规免疫反应；然而，有人推测先天免疫在某些疾病的发生和发展中的重要性不仅仅是“第一道防线”。自身免疫性疾病是由免疫系统过度激活引起的，是最具挑战性的科学和临床问题之一，对于它们的发病机制仍有许多需要了解的地方。我们旨在提供关于先天免疫在系统性自身免疫性疾病（包括类风湿关节炎、系统性红斑狼疮、干燥综合征、多发性肌炎和系统性硬化症）中的作用的现有文献的全面概述。本研究强调了正在研究用于治疗这些疾病的先天免疫途径或分子。
