University of Patras School of Health Sciences, Department of Pharmacy, Patras 265 04, Greece; United Arab Emirates University, College of Medicine and Health Sciences, Department of Pathology, Al-Ain, UAE; United Arab Emirates University, Zayed Center of Health Sciences, Al-Ain, UAE.
Medical Center of Crete, Irakleion, 700 03, Greece.
Am J Hum Genet. 2020 Oct 1;107(4):589-595. doi: 10.1016/j.ajhg.2020.08.005.
In the post-genomic era, genomic medicine interventions as a key component of personalized medicine and tailored-made health care are greatly anticipated following recent scientific and technological advances. Indeed, large-scale sequencing efforts that explore human genomic variation have been initiated in several, mostly developed, countries across the globe, such as the United States, the United Kingdom, and a few others. Here, we highlight the successful implementation of large-scale national genomic initiatives, namely the Genome of Greece (GoGreece) and the DNA do Brasil (DNABr), aiming to emphasize the importance of implementing such initiatives in developing countries. Based on this experience, we also provide a roadmap for replicating these projects in other low-resource settings, thereby bringing genomic medicine in these countries closer to clinical fruition.
在后基因组时代，基于最近的科学技术进步，基因组医学干预作为个性化医学和定制化医疗的关键组成部分备受期待。事实上，全球多个国家（如美国、英国和其他一些国家）已经开展了大规模的人类基因组变异探索测序工作。在这里，我们强调了成功实施大规模国家基因组计划的重要性，例如希腊基因组计划（GoGreece）和巴西 DNA 计划（DNABr），旨在强调在发展中国家实施此类计划的重要性。基于这一经验，我们还为在其他资源匮乏的环境中复制这些项目提供了路线图，从而使这些国家的基因组医学更接近临床实现。
