Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.
Children's Hospital, Pediatric Research Center, University of Helsinki, and Helsinki University Hospital, 00014 Helsinki, Finland.
Cell. 2020 Oct 15;183(2):324-334.e5. doi: 10.1016/j.cell.2020.08.047. Epub 2020 Oct 1.
Infants born by vaginal delivery are colonized with maternal fecal microbes. Cesarean section (CS) birth disturbs mother-to-neonate transmission. In this study (NCT03568734), we evaluated whether disturbed intestinal microbiota development could be restored in term CS-born infants by postnatal, orally delivered fecal microbiota transplantation (FMT). We recruited 17 mothers, of whom seven were selected after careful screening. Their infants received a diluted fecal sample from their own mothers, taken 3 weeks prior to delivery. All seven infants had an uneventful clinical course during the 3-month follow-up and showed no adverse effects. The temporal development of the fecal microbiota composition of FMT-treated CS-born infants no longer resembled that of untreated CS-born infants but showed significant similarity to that of vaginally born infants. This proof-of-concept study demonstrates that the intestinal microbiota of CS-born infants can be restored postnatally by maternal FMT. However, this should only be done after careful clinical and microbiological screening.
阴道分娩的婴儿从母体粪便微生物中定植。剖宫产（CS）分娩会干扰母婴传播。在这项研究中（NCT03568734），我们评估了通过产后口服粪便微生物移植（FMT）是否可以恢复足月 CS 分娩婴儿受损的肠道微生物群发育。我们招募了 17 位母亲，其中 7 位经过仔细筛选后入选。她们的婴儿接受了来自母亲的稀释粪便样本，该样本是在分娩前 3 周采集的。在 3 个月的随访期间，所有 7 名婴儿的临床过程均未出现异常，且未出现任何不良反应。接受 FMT 的 CS 分娩婴儿的粪便微生物组成的时间发展不再类似于未接受治疗的 CS 分娩婴儿，而是与阴道分娩婴儿具有显著相似性。这项概念验证研究表明，通过母亲的 FMT 可以在产后恢复 CS 分娩婴儿的肠道微生物群。然而，这应该仅在经过仔细的临床和微生物筛选后进行。
