Sharifuzzaman Md, Chhetry Ashok, Zahed Md Abu, Yoon Sang Hyuk, Park Chan I, Zhang Shipeng, Chandra Barman Sharat, Sharma Sudeep, Yoon Hyosang, Park Jae Yeong
Department of Electronic Engineering, Advanced Sensor and Energy Research (ASER) Laboratory, Kwangwoon University, 447-1, Seoul, 139-701, Republic of Korea.
Department of Electronic Engineering, Advanced Sensor and Energy Research (ASER) Laboratory, Kwangwoon University, 447-1, Seoul, 139-701, Republic of Korea.
Biosens Bioelectron. 2020 Dec 1;169:112637. doi: 10.1016/j.bios.2020.112637. Epub 2020 Sep 23.
Three-dimensional (3D) porous laser-guided graphene (LGG) electrodes on elastomeric substrates are of great significance for developing flexible functional electronics. However, the high sheet resistance and poor mechanical properties of LGG sheets obstruct their full exploitation as electrode materials. Herein, we applied 2D MXene nanosheets to functionalize 3D LGG sheets via a C-O-Ti covalent crosslink to obtain an LGG-MXene hybrid scaffold exhibited high conductivity and improved electrochemistry with fast heterogeneous electron transfer (HET) rate due to the synergistic effect between LGG and MXene. Then we transferred the obtained hybrid scaffold onto PDMS to engineer a smart, flexible, and stretchable multifunctional sensors-integrated wound bandage capable of assessing uric acid (UA), pH, and temperature at the wound site. The integrated UA sensor exhibited a rapid response toward UA in an extended wide range of 50-1200 μM with a high sensitivity of 422.5 μA mM cm and an ultralow detection limit of 50 μM. Additionally, the pH sensor demonstrated a linear Nernstian response (R = 0.998) with a high sensitivity of -57.03 mV pH in the wound relevant pH range of 4-9. The temperature sensor exhibited a fast and stable linear resistive response to the temperature variations in the physiological range of 25-50 °C with an excellent sensitivity and correlation coefficient of 0.09% ⁰C and 0.999, respectively. We anticipate that this stretchable and flexible smart bandage could revolutionize wound care management and have profound impacts on the therapeutic outcomes.
在弹性体基底上制备的三维（3D）多孔激光诱导石墨烯（LGG）电极对于开发柔性功能电子器件具有重要意义。然而，LGG片材的高面电阻和较差的机械性能阻碍了它们作为电极材料的充分利用。在此，我们通过C-O-Ti共价交联将二维MXene纳米片应用于3D LGG片材的功能化，以获得一种LGG-MXene混合支架，由于LGG和MXene之间的协同效应，该支架具有高导电性并改善了电化学性能，具有快速的异质电子转移（HET）速率。然后，我们将获得的混合支架转移到聚二甲基硅氧烷（PDMS）上，设计了一种智能、柔性且可拉伸的多功能集成伤口绷带传感器，能够评估伤口部位的尿酸（UA）、pH值和温度。集成的UA传感器在50-1200 μM的宽范围内对UA表现出快速响应，灵敏度高达422.5 μA mM cm，检测限低至50 μM。此外，pH传感器在4-9的伤口相关pH范围内表现出线性能斯特响应（R = 0.998），灵敏度高达-57.03 mV/pH。温度传感器在25-50 °C的生理温度范围内对温度变化表现出快速且稳定的线性电阻响应，灵敏度和相关系数分别为0.09%/°C和0.999。我们预计这种可拉伸且柔性的智能绷带可能会彻底改变伤口护理管理，并对治疗效果产生深远影响。
