Reid Gregory, Magarotto Fabio, Marsano Anna, Pozzobon Michela
Department of Cardiac Surgery, University Hospital Basel, 4031 Basel, Switzerland.
Department of Biomedicine, University of Basel, 4031 Basel, Switzerland.
Bioengineering (Basel). 2020 Sep 30;7(4):118. doi: 10.3390/bioengineering7040118.
Large-scale muscle injury in humans initiates a complex regeneration process, as not only the muscular, but also the vascular and neuro-muscular compartments have to be repaired. Conventional therapeutic strategies often fall short of reaching the desired functional outcome, due to the inherent complexity of natural skeletal muscle. Tissue engineering offers a promising alternative treatment strategy, aiming to achieve an engineered tissue close to natural tissue composition and function, able to induce long-term, functional regeneration after in vivo implantation. This review aims to summarize the latest approaches of tissue engineering skeletal muscle, with specific attention toward fabrication, neuro-angiogenesis, multicellularity and the biochemical cues that adjuvate the regeneration process.
人类的大规模肌肉损伤会引发一个复杂的再生过程，因为不仅肌肉组织，而且血管和神经肌肉部分都必须得到修复。由于天然骨骼肌固有的复杂性，传统的治疗策略往往难以达到理想的功能结果。组织工程提供了一种有前景的替代治疗策略，旨在构建一种接近天然组织组成和功能的工程组织，能够在体内植入后诱导长期的功能性再生。这篇综述旨在总结组织工程骨骼肌的最新方法，特别关注制造、神经血管生成、多细胞性以及促进再生过程的生化线索。
