Rock G, Decary F, McCombie N, Smiley R K, Aye M T, Huebsch L
CMAJ. 1987 Aug 15;137(4):294-6.
Reports of successful transplantation of bone marrow obtained from unrelated donors who were histocompatibility leukocyte antigen (HLA) identical prompted the Canadian Red Cross Blood Transfusion Service in Ottawa to assess the possibility of developing a bone marrow donor registry in Canada. We sent a pamphlet that explained the program to 1568 people who had undergone apheresis and asked them to reply, stating their interest. At the same time the pamphlets and a poster were placed in the blood donor clinic. We received 1232 replies (78.6%) from the apheresis donors, 838 (68.0%) of which indicated a willingness to attend information sessions. Of the 7158 people who gave blood during the 3-month study period, 225 (3.1%) were interested. At the time this paper was written 47 information sessions had been held, and 721 people had attended, 624 (86.5%) of whom had signed a consent form. This indicates a clear interest in a bone marrow donation program. We believe that the ethical issues are overcome by requesting the donation before identification of any patient. From our experience a national registry of unrelated donors seems feasible, and steps are being taken to implement such a program.
从人类白细胞抗原（HLA）匹配的无关供体获取骨髓并成功移植的报告，促使渥太华的加拿大红十字会输血服务中心评估在加拿大建立骨髓供体登记处的可能性。我们向1568名接受过单采术的人发送了一份解释该项目的宣传册，并请他们回复，表明他们的兴趣。与此同时，宣传册和一张海报被放置在献血诊所。我们收到了1232名单采术供体的回复（78.6%），其中838份（68.0%）表示愿意参加信息发布会。在为期3个月的研究期间献血的7158人中，有225人（3.1%）感兴趣。在撰写本文时，已经举办了47场信息发布会，721人参加，其中624人（86.5%）签署了同意书。这表明对骨髓捐赠项目有明显兴趣。我们认为，在确定任何患者之前请求捐赠可以克服伦理问题。根据我们的经验，建立一个无关供体的国家登记处似乎是可行的，并且正在采取措施实施这样一个项目。
