Department of Pharmacology, School of Pharmacy, Marmara University, İstanbul, Turkey.
Department of Pharmacognosy, School of Pharmacy, Trakya University, Edirne, Turkey.
Int J Impot Res. 2020 Dec;33(8):844-853. doi: 10.1038/s41443-020-00356-w. Epub 2020 Oct 2.
The aim of this study is to examine the possible benefits of exercise and caloric restriction (CR) on cardiovascular hemodynamics, erectile function, and antioxidant system in metabolic syndrome (MS). Sixty male Spraque-Dawley rats were divided into five groups; control, MS, MS + CR, MS + exercise (EXC), and MS + CR + EXC. To induce MS, 10% fructose solution was applied for 3 months. Thereafter, in CR groups calorie was restricted 40% and in EXC groups swimming was performed for 6 weeks. Body weight, blood glucose, and blood pressure (BP) levels were measured before and after MS induction and at the end of the experiment. After decapitation, tumor necrosis factor (TNF)-α, adiponectin (ADP), and plasminogen activator inhibitor (PAI)-1 levels were investigated in blood, oxidative stress parameters were examined in heart, aorta, and corpus cavernosum (CC) tissues. Isometric contraction in isolated tissue bath was studied in aorta and CC tissues. Animals subjected to exercise and CR had decreased BP and blood glucose levels. Impaired contraction-relaxation responses in MS group were improved with exercise and CR. MS-induced increase in TNF-α, PAI-1, malondialdehyde (MDA), and decrease in ADP, glutathione (GSH), and superoxide dismutase (SOD) were normalized with exercise and CR. Exercise and CR may be beneficial against changes in cardiovascular hemodynamics caused by MS.
本研究旨在探讨运动和热量限制（CR）对代谢综合征（MS）患者心血管血液动力学、勃起功能和抗氧化系统的可能益处。60 只雄性 Spraque-Dawley 大鼠分为五组：对照组、MS 组、MS+CR 组、MS+EXC 组和 MS+CR+EXC 组。为了诱导 MS，应用 10%果糖溶液 3 个月。此后，在 CR 组中，热量限制 40%，在 EXC 组中，游泳训练 6 周。在 MS 诱导前后和实验结束时测量体重、血糖和血压（BP）水平。断头后，在血液中检测肿瘤坏死因子（TNF）-α、脂联素（ADP）和纤溶酶原激活物抑制剂（PAI）-1 水平，在心脏、主动脉和海绵体（CC）组织中检查氧化应激参数。在主动脉和 CC 组织的离体组织浴中研究等长收缩。运动和 CR 可降低 MS 组的 BP 和血糖水平。MS 组收缩-松弛反应受损，经运动和 CR 可得到改善。MS 诱导的 TNF-α、PAI-1、丙二醛（MDA）增加，ADP、谷胱甘肽（GSH）和超氧化物歧化酶（SOD）减少，经运动和 CR 可恢复正常。运动和 CR 可能有益于对抗 MS 引起的心血管血液动力学变化。
