α-突触核蛋白病实验模型中的炎症反应。
Inflammation in Experimental Models of α-Synucleinopathies.
机构信息
Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.
出版信息
Mov Disord. 2021 Jan;36(1):37-49. doi: 10.1002/mds.28264. Epub 2020 Oct 3.
Abstract
Neuroinflammation has long been associated with central nervous system pathology in α-synucleinopathy disorders including Parkinson's disease and multiple system atrophy. In the past decade, research-focused efforts in preclinical and experimental models have rallied around this idea, and considerable effort has been made to delineate critical neuroinflammatory processes. In this article, we discuss challenges in preclinical research, notably the use of animal models to recapitulate and dissect disease phenotypes as well as the need for more sensitive, reliable radiotracers to detect on-target efficacy of immunomodulatory treatments in both human Parkinson's disease as well as preclinical models. © 2020 International Parkinson and Movement Disorder Society.
摘要
神经炎症与包括帕金森病和多系统萎缩在内的α-突触核蛋白病的中枢神经系统病理学长期相关。在过去的十年中，临床前和实验模型中的研究重点围绕着这一观点，并且已经做出了相当大的努力来描绘关键的神经炎症过程。在本文中，我们讨论了临床前研究中的挑战，特别是使用动物模型来重现和剖析疾病表型，以及需要更敏感、可靠的放射性示踪剂来检测免疫调节治疗在人类帕金森病和临床前模型中的靶向疗效。
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