The principles, technique of measurement, and clinical significance of free drugs are reviewed. Albumin, alpha-1-acid glycoprotein, and lipoprotein are the main drug-binding proteins in blood. Variations of the concentrations of these proteins owing to disease would result in changes in the free drug levels. These levels may be determined by equilibrium dialysis, ultrafiltration, and other techniques.
本文综述了游离药物的原理、测量技术及临床意义。白蛋白、α1-酸性糖蛋白和脂蛋白是血液中主要的药物结合蛋白。疾病导致这些蛋白质浓度的变化会引起游离药物水平的改变。这些水平可通过平衡透析、超滤及其他技术来测定。
