Hu Xingjiang, Xu Nana, Yang Xi, Hu Xi, Zheng Yunliang, Zhang Qiao
Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, Department of Clinical Pharmacy, The First Affiliated Hospital, Zhejiang University School of Medicine, 310003, Hangzhou, People's Republic of China.
AMB Express. 2020 Oct 4;10(1):179. doi: 10.1186/s13568-020-01114-3.
Nigella A, also named Sieboldianoside A, has been extracted from many kinds of Traditional Chinese Medicine (TCM), such as Nigella glandulifera, Stauntonia chinensis DC., and the leaves of Acanthopanax sieboldianus. Nigella A exhibited potential analgesic, anti-inflammatory, anti-tumor, and antioxidant activities. However, whether Nigella A could treat ulcerative colitis (UC) is still unknown. As saponins always be regarded as the kinds of ingredients that could regulate immunity and intestinal flora. This research aimed to investigate the therapeutic effect of Nigella A on UC and explore its effect on intestinal flora. We noted that Nigella A and Sulfasalazine (SASP) could significantly improve the signs and symptoms, alleviate colonic pathological injury in DSS-induced mice. The changing of many specific bacterial genus such as Lactobacillus, Porphyromonadaceae, Bacteroides and Escherichia might closely related to the recovery of intestinal inflammatory response. This study initially confirmed the therapeutic effect of Nigella A and SASP on DSS-induced colitis by improving the diversity of intestinal microbial composition. Nigella A has the potential to be developed for the treatment of UC and other disorders related to the imbalance of intestinal flora.
黑种草素A，也被称为西博尔德皂苷A，已从多种中药中提取出来，如腺毛黑种草、中华野木瓜和刺五加叶。黑种草素A具有潜在的镇痛、抗炎、抗肿瘤和抗氧化活性。然而，黑种草素A是否能治疗溃疡性结肠炎（UC）仍不清楚。由于皂苷一直被视为能够调节免疫力和肠道菌群的成分类型。本研究旨在探讨黑种草素A对UC的治疗作用，并探索其对肠道菌群的影响。我们注意到黑种草素A和柳氮磺胺吡啶（SASP）可显著改善症状体征，减轻DSS诱导的小鼠结肠病理损伤。许多特定细菌属的变化，如乳酸杆菌属、卟啉单胞菌科、拟杆菌属和大肠杆菌，可能与肠道炎症反应的恢复密切相关。本研究初步证实了黑种草素A和SASP通过改善肠道微生物组成的多样性对DSS诱导的结肠炎具有治疗作用。黑种草素A有潜力被开发用于治疗UC和其他与肠道菌群失衡相关的疾病。
