Postgraduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University, UNINOVE, São Paulo, Brazil.
Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
Oral Dis. 2021 Jul;27(5):1205-1216. doi: 10.1111/odi.13662. Epub 2020 Oct 26.
To compare the efficacy of photobiomodulation to that of topical clobetasol 0.05% in patients with symptomatic oral lichen planus (OLP).
Thirty-four patients with symptomatic OLP were randomly allocated into two groups: (a) the Control group (n = 17), application of topical clobetasol propionate 0.05% three times a day for 30 consecutive days with laser placebo applied twice a week to mask the treatment, and (b) the photobiomodulation group (n = 17), laser application twice a week, totalling 8 sessions, and gel placebo for 30 consecutive days to mask the treatment. Evaluations were performed once a week during treatment and 30, 60 and 90 days after treatment. The following parameters were evaluated: pain, clinical scores, clinical resolution and recurrence rate.
Photobiomodulation and propionate clobetasol 0.05% were able to significantly decrease pain in oral lichen planus patients and improve clinical scores during treatment and follow-up. Both the Control and photobiomodulation groups presented similar clinical resolution and recurrence rates. Most importantly, no difference was observed between treatments during treatment and follow-up.
These findings indicate that photobiomodulation twice a week is as effective as corticoid therapy in treating oral lichen planus. Moreover, photobiomodulation is a safe and non-invasive therapy with the remarkable advantage of no adverse effects.
比较光生物调节疗法与 0.05%卤倍他索外用治疗口腔扁平苔藓（OLP）患者的疗效。
34 例有症状的 OLP 患者随机分为两组：（a）对照组（n=17），每日外用丙酸氯倍他索 0.05%三次，共 30 天，同时每周两次应用激光安慰剂掩盖治疗；（b）光生物调节组（n=17），每周应用激光两次，共 8 次，同时在 30 天内使用凝胶安慰剂掩盖治疗。治疗期间和治疗后 30、60 和 90 天进行评估。评估参数包括疼痛、临床评分、临床缓解率和复发率。
光生物调节和丙酸氯倍他索 0.05%均可显著减轻口腔扁平苔藓患者的疼痛，并改善治疗和随访期间的临床评分。对照组和光生物调节组的临床缓解率和复发率相似。最重要的是，治疗期间和随访期间两种治疗方法之间没有差异。
这些发现表明，每周两次的光生物调节与皮质激素治疗口腔扁平苔藓同样有效。此外，光生物调节是一种安全、非侵入性的治疗方法，具有显著的无不良反应优势。
