Soh Wei Kang, Cheah Kwok Fu, Veettil Sajesh K, Pandiar Deepak, Nimbalkar Smita, Gopinath Divya
School of Dentistry, International Medical University, Kuala Lumpur, Malaysia.
Department of Pharmacy Practice, School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia.
Eur J Dent. 2024 Oct;18(4):976-986. doi: 10.1055/s-0044-1782213. Epub 2024 May 14.
Photobiomodulation therapy (PBMT) is a non-invasive and the latest form of therapy used in the treatment of non oncological diseases as well as cancers of various types and locations. The aim of this study was to systematically review and assess the efficacy of PBMT in managing oral lichen planus (OLP) compared to the interventions. A systematic review and meta-analysis were implemented according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. An electronic search using PubMed, Scopus, and Cochrane was conducted to retrieve relevant studies published until June 2023. The outcomes evaluated included the reduction in pain score and clinical severity scores (Prospero No CRD42023428626). A total of eight studies were identified for qualitative synthesis. The pooled analysis incorporating six studies revealed that there are no significant differences for both mean pain score (mean difference [MD] = 0.21, 95% confidence interval [CI] = -0.51, 0.93) as well as clinical score (MD = -0.08, 95% CI = -0.4, 0.25) between PBMT and comparison groups. Subgroup analysis based on corticosteroids as controls showed that there was no significant difference in mean reduction in pain score between PBMT and topical steroids (MD = 0.38, 95% CI = -0.54, 1.31). PBMT is as effective as other interventions in the treatment of OLP, though not superior, and can be a promising alternative treatment for cases resistant to steroids or when steroids are contraindicated. Further studies are recommended to standardize the optimal settings for the treatment of OLP.
光生物调节疗法（PBMT）是一种非侵入性的最新治疗方法，用于治疗非肿瘤性疾病以及各种类型和部位的癌症。本研究的目的是系统评价和评估PBMT与其他干预措施相比在治疗口腔扁平苔藓（OLP）方面的疗效。根据系统评价和Meta分析的首选报告项目（PRISMA）指南进行了系统评价和Meta分析。通过PubMed、Scopus和Cochrane进行电子检索，以检索截至2023年6月发表的相关研究。评估的结果包括疼痛评分和临床严重程度评分的降低（国际前瞻性系统评价注册库编号CRD42023428626）。共确定了八项研究进行定性综合分析。纳入六项研究的汇总分析显示，PBMT组与对照组之间在平均疼痛评分（平均差[MD]=0.21，95%置信区间[CI]=-0.51，0.93）以及临床评分（MD=-0.08，95%CI=-0.4，0.25）方面均无显著差异。以皮质类固醇为对照的亚组分析表明，PBMT与局部类固醇在平均疼痛评分降低方面无显著差异（MD=0.38，95%CI=-0.54，1.31）。PBMT在治疗OLP方面与其他干预措施一样有效，虽不具有优越性，但对于对类固醇耐药或类固醇禁忌的病例可能是一种有前景的替代治疗方法。建议进一步研究以规范OLP治疗的最佳设置。
