Department of Pathobiology and Population Sciences, Royal Veterinary College, University of London, Hertfordshire, UK; London Centre for Neglected Tropical Disease Research, School of Public Health, Imperial College London, London, UK.
Department of Pathobiology and Population Sciences, Royal Veterinary College, University of London, Hertfordshire, UK; London Centre for Neglected Tropical Disease Research, School of Public Health, Imperial College London, London, UK.
Trends Parasitol. 2020 Dec;36(12):959-969. doi: 10.1016/j.pt.2020.08.005. Epub 2020 Oct 1.
Traditionally, the protozoan parasite Toxoplasma gondii has been thought of as relevant to public health primarily within the context of congenital toxoplasmosis or postnatally acquired disease in immunocompromised patients. However, latent T.gondii infection has been increasingly associated with a wide variety of neuropsychiatric disorders and, more recently, causal frameworks for these epidemiological associations have been proposed. We present assimilated evidence on the associations between T.gondii and various human neuropsychiatric disorders and outline how these may be explained within a unifying causal framework. We argue that the occult effects of latent T.gondii infection likely outweigh the recognised overt morbidity caused by toxoplasmosis, substantially raising the public health importance of this parasite.
传统上，原虫寄生虫刚地弓形虫主要被认为与公共卫生有关，主要是在先天性弓形体病或免疫功能低下患者后天获得的疾病的背景下。然而，潜伏的刚地弓形虫感染与各种各样的神经精神疾病越来越相关，最近，这些流行病学关联的因果框架已经被提出。我们介绍了关于刚地弓形虫与各种人类神经精神疾病之间关联的综合证据，并概述了如何在一个统一的因果框架内解释这些关联。我们认为，潜伏的刚地弓形虫感染的隐性影响可能超过弓形虫病引起的公认显性发病率，大大提高了这种寄生虫的公共卫生重要性。
