Department of Internal Medicine, Temple University Hospital, Philadelphia, PA.
Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, PA.
Clin Colorectal Cancer. 2021 Mar;20(1):e1-e4. doi: 10.1016/j.clcc.2020.07.007. Epub 2020 Jul 30.
Oxaliplatin-induced immune thrombocytopenia is a rare manifestation of oxaliplatin hypersensitivity, presenting as an acute onset of severe thrombocytopenia after oxaliplatin administration. No standard therapeutic approach outside of permanent discontinuation of oxaliplatin exists. Here, we present a case of oxaliplatin-induced immune thrombocytopenia occurring after oxaliplatin retreatment for metastatic colon cancer. Possible mechanisms of disease and approach to treatment are discussed.
奥沙利铂引起的免疫性血小板减少症是奥沙利铂过敏的一种罕见表现，在奥沙利铂给药后急性发作严重血小板减少症。除了永久停用奥沙利铂外，目前尚无标准的治疗方法。在这里，我们报告了一例转移性结肠癌奥沙利铂再治疗后发生的奥沙利铂诱导的免疫性血小板减少症病例。讨论了疾病的可能发病机制和治疗方法。
