Department of Otolaryngology, Medical Faculty of Başkent University, Ankara, Turkey.
J Int Adv Otol. 2023 Mar;19(2):130-139. doi: 10.5152/iao.2023.21560.
It is ascertained that the compressed high-intensity radar pulse (CHIRP) is an effective stimulus in auditory electrophysiology. This study aims to investigate whether Narrow Band Level Specific Claus Elberling Compressed High-Intensity Radar Pulse (NB LS CE-CHIRP) stimulus is an effective stimulus in the vestibular evoked myogenic potentials test.
A case-control study was designed. Fifty-four healthy participants with no vertigo complaints and 50 patients diagnosed with acute peripheral vestibular pathology were enrolled in this study. Cervical and ocular vestibular evoked myogenic potential tests (cervical vestibular evoked myogenic potentials and ocular vestibular evoked myogenic potentials) with 500 Hz tone burst and 500 Hz Narrow Band Level Specific CE-CHIRP stimulations were performed on all participants. In addition, cervical vestibular evoked myogenic potentials and ocular vestibular evoked myogenic potentials tests with 1000 Hz tone burst and 1000 Hz Narrow Band Level Specific CE-CHIRP were performed on 24 Meniere's disease patients. P1 latency, N1 latency, amplitude, threshold, and the asymmetry ratio of responses were recorded.
In healthy participants, with CHIRP stimulus, shorter P1 latency (P < .001), shorter N1 latency (P < .001), and lower threshold (P = .003) were obtained in the cervical vestibular evoked myogenic potentials test; shorter P1 latency (P < .001), shorter N1 latency (P < .001), higher amplitude (P < .001), and lower threshold (P < .001) were obtained in ocular vestibular evoked myogenic potentials test. In symptomatic ears of patients, with CHIRP stimulus, shorter P1 latency (P < .001), shorter N1 latency (P < .001), and lower threshold (P=.013 in cervical vestibular evoked myogenic potentials; P=.015 in ocular vestibular evoked myogenic potentials) were obtained in cervical vestibular evoked myogenic potentials and ocular vestibular evoked myogenic potentials tests. In asymptomatic ears of patients, with CHIRP stimulus, shorter P1 latency (P < .001) and shorter N1 latency (P < .001) were obtained in the cervical vestibular evoked myogenic potentials test; shorter P1 latency (P < .001), shorter N1 latency (P < .001), higher amplitude (P < .001), and lower threshold (P=.006) were obtained in ocular vestibular evoked myogenic potentials test.
Our results suggest that due to higher response rates, shorter latencies, higher amplitude, and lower threshold values, the Narrow Band Level Specific CE-CHIRP stimulus is an effective stimulus for both cervical vestibular evoked myogenic potentials and ocular vestibular evoked myogenic potentials tests.
已证实压缩高强度雷达脉冲（CHIRP）是听觉电生理学中的一种有效刺激。本研究旨在探讨窄带水平特异性克劳修斯·埃尔贝林压缩高强度雷达脉冲（NB LS CE-CHIRP）刺激是否为前庭诱发肌源性电位测试中的有效刺激。
设计了一项病例对照研究。本研究纳入了 54 名无眩晕症状的健康参与者和 50 名被诊断为急性外周前庭病变的患者。对所有参与者进行了 500 Hz 啁啾和 500 Hz 窄带水平特异性 CE-CHIRP 刺激的颈和眼前庭诱发肌源性电位测试（颈前庭诱发肌源性电位和眼前庭诱发肌源性电位）。此外，对 24 名梅尼埃病患者进行了 1000 Hz 啁啾和 1000 Hz 窄带水平特异性 CE-CHIRP 的颈和眼前庭诱发肌源性电位测试。记录 P1 潜伏期、N1 潜伏期、振幅、阈值和反应的不对称比。
在健康参与者中，使用 CHIRP 刺激时，颈前庭诱发肌源性电位测试中 P1 潜伏期更短（P <.001）、N1 潜伏期更短（P <.001）和阈值更低（P =.003）；眼前庭诱发肌源性电位测试中 P1 潜伏期更短（P <.001）、N1 潜伏期更短（P <.001）、振幅更高（P <.001）和阈值更低（P <.001）。在患者的症状耳中，使用 CHIRP 刺激时，颈前庭诱发肌源性电位和眼前庭诱发肌源性电位测试中 P1 潜伏期更短（P <.001）、N1 潜伏期更短（P <.001）和阈值更低（颈前庭诱发肌源性电位：P=.013；眼前庭诱发肌源性电位：P=.015）。在患者的无症状耳中，使用 CHIRP 刺激时，颈前庭诱发肌源性电位测试中 P1 潜伏期更短（P <.001）、N1 潜伏期更短（P <.001）；眼前庭诱发肌源性电位测试中 P1 潜伏期更短（P <.001）、N1 潜伏期更短（P <.001）、振幅更高（P <.001）和阈值更低（P=.006）。
我们的结果表明，由于反应率更高、潜伏期更短、振幅更高和阈值更低，窄带水平特异性 CE-CHIRP 刺激是颈前庭诱发肌源性电位和眼前庭诱发肌源性电位测试的有效刺激。
