Jain Jyoti, Gupta Nidhi, Mathur Rati, Nimesh Surendra, Mathur Sandeep K
Department of Biochemistry, SMS Medical College and Hospital, Jaipur, Rajasthan India.
Research and Development Cell, Department of Biotechnology, IIS (Deemed to be University), Jaipur, Rajasthan India.
Indian J Clin Biochem. 2020 Oct;35(4):451-457. doi: 10.1007/s12291-019-00843-y. Epub 2019 Aug 3.
A surge to increase the production via usage of chemicals at both industrial and agricultural arena has forced humans to be routinely and imprudently exposed to a wide variety of endocrine disrupting chemicals. The overall aim of the study was to evaluate possible relation that might exist between bisphenol-A (BPA) and the adipose tissue hormones, and further impact on adiposopathy. In the present study, the role of BPA, an "endocrine disruptor" with respect to adiposopathy was evaluated in type 2 diabetes mellitus patients. For the study, 150 healthy control subjects and 150 newly diagnosed diabetes patients were recruited. Fasting venous blood samples was analyzed for several biochemical parameters such as serum glucose, lipid profile, insulin, adiponectin, leptin, TNF-α, IL-6, IL-1, free fatty acid. Concentrations of BPA were also measured both in control and diabetic subjects. Serum BPA concentration was found to be significantly higher in diabetic subjects in comparison to the control subjects. Levels of BPA were found to be positively correlated with BMI and WC in diabetic subjects. Also, it was found to be positively correlated with leptin and negatively correlated with adiponectin in diabetic subjects. Therefore, the current study suggested more deleterious effect of BPA on diabetes and its pathophysiology.
在工业和农业领域通过使用化学物质来提高产量的热潮，迫使人类经常且不加谨慎地接触各种各样的内分泌干扰化学物质。该研究的总体目标是评估双酚A（BPA）与脂肪组织激素之间可能存在的关系，以及对脂肪病变的进一步影响。在本研究中，对2型糖尿病患者评估了作为“内分泌干扰物”的BPA在脂肪病变方面的作用。为进行该研究，招募了150名健康对照者和150名新诊断的糖尿病患者。对空腹静脉血样本进行了多项生化参数分析，如血糖、血脂、胰岛素、脂联素、瘦素、肿瘤坏死因子-α、白细胞介素-6、白细胞介素-1、游离脂肪酸。还测量了对照者和糖尿病患者的BPA浓度。发现糖尿病患者的血清BPA浓度显著高于对照者。在糖尿病患者中，BPA水平与体重指数和腰围呈正相关。此外，在糖尿病患者中，它与瘦素呈正相关，与脂联素呈负相关。因此，当前研究表明BPA对糖尿病及其病理生理学有更有害的影响。
