Dua Sagar, Singh Praveen, Saha Sarama
Department of Biochemistry, AIIMS, Rishikesh, India.
Indian J Clin Biochem. 2020 Oct;35(4):482-487. doi: 10.1007/s12291-019-00850-z. Epub 2019 Sep 18.
Dyslipidaemia, metabolic syndrome, diabetes mellitus and arterial hypertension contribute to the risk of cognitive disorder and dementia. However very few and conflicting results are available with respect to the impact of lipoprotein ratios on cognitive functions in healthy individuals. Therefore, this study was aimed to investigate the association of lipid profile and its ratios with reaction time in young healthy individuals. 89 individuals (54 male and 35 female) with mean age of 31.20 ± 3.19 years were selected for this observational study conducted at AIIMS Rishikesh and written consent was obtained. TC, TG, HDL were measured by semi auto analyzer following the manufacturers' instruction and LDL was calculated by Friedewald formula. Reaction time (simple and choice reaction time) was assessed using a software package, Deary-Liewald reaction time task. Association of various parameters was calculated by pearson's correlation coefficient using SPSS version 23.0. Reaction time showed significant negative association with BMI (r = - 0.323, = 0.002) in total study participants as well as with TG (r = - 0.440, = 0.008) and TG/HDL (r = - 0.402, = 0.025) in female individuals. From this study, it could be concluded that TG/HDL ratio, the superlative predictor of concomitant presence of cardiovascular disease, insulin resistance and metabolic syndrome may be considered as a biomarker for assessment of cognitive function in young healthy female individuals.
血脂异常、代谢综合征、糖尿病和动脉高血压会增加认知障碍和痴呆的风险。然而，关于脂蛋白比例对健康个体认知功能的影响，现有研究结果很少且相互矛盾。因此，本研究旨在调查年轻健康个体的血脂谱及其比例与反应时间之间的关联。本观察性研究在里希凯什全印医学科学研究所进行，选取了89名个体（54名男性和35名女性），平均年龄为31.20 ± 3.19岁，并获得了书面知情同意。按照制造商的说明，使用半自动分析仪测量总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL），并通过Friedewald公式计算低密度脂蛋白（LDL）。使用软件包Deary-Liewald反应时间任务评估反应时间（简单反应时间和选择反应时间）。使用SPSS 23.0版本通过Pearson相关系数计算各种参数之间的关联。在所有研究参与者中，反应时间与体重指数（BMI）呈显著负相关（r = -0.323，P = 0.002），在女性个体中，反应时间与甘油三酯（r = -0.440，P = 0.008）和甘油三酯/高密度脂蛋白（r = -0.402，P = 0.025）呈显著负相关。从本研究可以得出结论，甘油三酯/高密度脂蛋白比例作为心血管疾病、胰岛素抵抗和代谢综合征并存的最佳预测指标，可被视为评估年轻健康女性个体认知功能的生物标志物。
