Chen Lu, Zhu Lin, Lu Di, Wu Zhe, Han Yanbing, Xu Puying, Chang Lvhua, Wu Qian
Department of Neurology, First Affiliated Hospital, Kunming Medical University, Kunming, China.
Biomedicine Engineering Research Centre, Kunming Medical University, Kunming, China.
Front Mol Neurosci. 2020 Sep 4;13:554547. doi: 10.3389/fnmol.2020.554547. eCollection 2020.
Epilepsy is a chronic brain dysfunction induced by an abnormal neuronal discharge that is caused by complicated psychopathologies. Recently, accumulating studies have revealed a close relationship between inflammation and epilepsy. Specifically, microglia and astrocytes are important inflammatory cells in the central nervous system (CNS) that have been proven to be related to the pathogenesis and development of epilepsy. Additionally, interleukin 4 (IL-4) is an anti-inflammatory factor that can regulate microglia and astrocytes in many aspects. This review article focuses on the regulatory role of IL-4 in the pathological changes of glial cells related to epilepsy. We additionally propose that IL-4 may play a protective role in epileptogenesis and suggest that IL-4 may be a novel therapeutic target for the treatment of epilepsy.
癫痫是一种由复杂精神病理导致的异常神经元放电引起的慢性脑功能障碍。最近，越来越多的研究揭示了炎症与癫痫之间的密切关系。具体而言，小胶质细胞和星形胶质细胞是中枢神经系统（CNS）中的重要炎症细胞，已被证明与癫痫的发病机制和发展有关。此外，白细胞介素4（IL-4）是一种抗炎因子，可在许多方面调节小胶质细胞和星形胶质细胞。这篇综述文章重点关注IL-4在与癫痫相关的胶质细胞病理变化中的调节作用。我们还提出IL-4可能在癫痫发生中起保护作用，并表明IL-4可能是治疗癫痫的新型治疗靶点。
