Department of Otolaryngology- Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Front Endocrinol (Lausanne). 2020 Aug 18;11:565. doi: 10.3389/fendo.2020.00565. eCollection 2020.
Coronavirus diseases (COVID-19) is associated with high rates of morbidity and mortality and worse outcomes have been reported for various morbidities. The impact of pre-existing hypothyroidism on COVID-19 outcomes remains unknown. The aim of the present study was to identify a possible association between hypothyroidism and outcomes related to COVID-19 including hospitalization, need for mechanical ventilation, and all-cause mortality. All patients with a laboratory confirmed COVID-19 diagnosis in March 2020 in a large New York City health system were reviewed. Of the 3703 COVID-19 positive patients included in present study, 251 patients (6.8%) had pre-existing hypothyroidism and received thyroid hormone therapy. Hypothyroidism was not associated with increased risk of hospitalization [Adjusted Odds Ratio (OR): 1.23 (95% Confidence Interval (CI): 0.88- 1.70)], mechanical ventilation [OR: 1.17 (95% CI: 0.81-1.69)] nor death [OR: 1.07 (95% CI: 0.75-1.54)]. This study provides insight into the role of hypothyroidism on the outcomes of COVID-19 positive patients, indicating that no additional precautions or consultations are needed. However, future research into the potential complications of COVID-19 on the thyroid gland and function is warranted.
新型冠状病毒病（COVID-19）与高发病率和死亡率相关，并且已经报道了各种合并症的预后更差。先前存在的甲状腺功能减退症对 COVID-19 结局的影响尚不清楚。本研究旨在确定甲状腺功能减退症与 COVID-19 相关结局之间是否存在关联，包括住院、需要机械通气和全因死亡率。对 2020 年 3 月在纽约市一个大型医疗系统中实验室确诊为 COVID-19 的所有患者进行了回顾性研究。在本研究纳入的 3703 例 COVID-19 阳性患者中，251 例（6.8%）存在先前存在的甲状腺功能减退症并接受甲状腺激素治疗。甲状腺功能减退症与住院风险增加无关[校正比值比（OR）：1.23（95%置信区间（CI）：0.88-1.70）]、机械通气[OR：1.17（95%CI：0.81-1.69）]或死亡[OR：1.07（95%CI：0.75-1.54）]。本研究深入了解了甲状腺功能减退症对 COVID-19 阳性患者结局的作用，表明不需要额外的预防措施或咨询。然而，有必要对 COVID-19 对甲状腺和功能的潜在并发症进行进一步研究。
