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日本一起由肉毒杆菌A毒素引起的食物中毒事件。

A food-poisoning incident caused by Clostridium botulinum toxin A in Japan.

作者信息

Otofuji T, Tokiwa H, Takahashi K

出版信息

Epidemiol Infect. 1987 Aug;99(1):167-72. doi: 10.1017/s0950268800066991.

DOI:10.1017/s0950268800066991
PMID:3301378
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2249182/
Abstract

Food poisoning caused by Clostridium botulinum toxin A occurred in Japan. Eleven (31%) of 36 patients from 14 different areas died of botulism. Most of the patients had eaten commercial fried lotus-rhizome solid mustard without heating. The food, which implicated one of the special local products used for gifts in Kumamoto, was found to have been produced by a manufacturer in Kumamoto prefecture. In Fukuoka prefecture, two of three patients died on days 4 and 8 after eating the food; they had typical symptoms of botulism. A total of 42 packages of the food bought as gifts was collected from different districts in Fukuoka prefecture for examination for both organism and toxin. Thirteen of these (31%) were contaminated with the organism, and in 11 (26%) a small amount of toxin A had been produced.

摘要

日本发生了由肉毒杆菌A毒素引起的食物中毒事件。来自14个不同地区的36名患者中有11人(31%)死于肉毒中毒。大多数患者食用了未经加热的市售油炸藕片固体芥末。这种食品是熊本地区作为礼品使用的特色产品之一,经调查发现是由熊本县的一家制造商生产的。在福冈县,三名患者中有两名在食用该食品后的第4天和第8天死亡;他们具有典型的肉毒中毒症状。从福冈县不同地区收集了总共42份作为礼品购买的该食品,用于检测其中的微生物和毒素。其中13份(31%)被微生物污染,11份(26%)产生了少量的A毒素。

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本文引用的文献

1
ISOLATION AND CHARACTERIZATION OF A TOXIC MOIETY OF LOW MOLECULAR WEIGHT FROM CLOSTRIDIUM BOTULINUM TYPE A.A型肉毒杆菌低分子量毒性成分的分离与鉴定
J Bacteriol. 1965 May;89(5):1383-6. doi: 10.1128/jb.89.5.1383-1386.1965.
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Studies on immunity to toxins of Clostridium botulinum. I. A simplified procedure for isolation of type A toxin.肉毒梭菌毒素免疫研究。I. A型毒素分离的简化程序。
J Bacteriol. 1957 Jan;73(1):42-7. doi: 10.1128/jb.73.1.42-47.1957.
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Rapid bioassay for Clostridium botulinum type-E toxins by intravenous injection into mice.
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